Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

BACKGROUND: Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis). However, recent analyses of neovascularization are very complicated, and the mechanism of action...

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Detalles Bibliográficos
Autores principales: Shan, Liang, Xu, Ximing, Zhang, Jing, Cai, Peng, Gao, Han, Lu, Yingjie, Shi, Jiangang, Guo, Yinlong, Su, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425117/
https://www.ncbi.nlm.nih.gov/pubmed/34496740
http://dx.doi.org/10.1186/s10020-021-00368-2

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