The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility

YTHDF2 is responsible for maintaining the dynamic N(6)-methyladenosine (m(6)A) modification balance and influences a variety of cancers. We tested whether YTHDF2 gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). Howe...

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Autores principales: Wang, Zhiyuan, Zhuo, Zhenjian, Li, Linyan, Hua, Rui-Xi, Li, Li, Zhang, Jiao, Cheng, Jiwen, Zhou, Haixia, Li, Suhong, He, Jing, Yan, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425210/
https://www.ncbi.nlm.nih.gov/pubmed/34539889
http://dx.doi.org/10.7150/jca.62154
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author Wang, Zhiyuan
Zhuo, Zhenjian
Li, Linyan
Hua, Rui-Xi
Li, Li
Zhang, Jiao
Cheng, Jiwen
Zhou, Haixia
Li, Suhong
He, Jing
Yan, Shan
author_facet Wang, Zhiyuan
Zhuo, Zhenjian
Li, Linyan
Hua, Rui-Xi
Li, Li
Zhang, Jiao
Cheng, Jiwen
Zhou, Haixia
Li, Suhong
He, Jing
Yan, Shan
author_sort Wang, Zhiyuan
collection PubMed
description YTHDF2 is responsible for maintaining the dynamic N(6)-methyladenosine (m(6)A) modification balance and influences a variety of cancers. We tested whether YTHDF2 gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However, the rs3738067 A>G polymorphism showed no statistical significance with Wilms tumor susceptibility. Stratification analysis also revealed that there was no remarkable association of rs3738067 variant AG/GG genotype with Wilms tumor risk in every subgroup (age, gender, and clinical stages). In all, the results indicated YTHDF2 gene rs3738067 A>G polymorphism could not alter Wilms tumor risk significantly.
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spelling pubmed-84252102021-09-16 The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility Wang, Zhiyuan Zhuo, Zhenjian Li, Linyan Hua, Rui-Xi Li, Li Zhang, Jiao Cheng, Jiwen Zhou, Haixia Li, Suhong He, Jing Yan, Shan J Cancer Research Paper YTHDF2 is responsible for maintaining the dynamic N(6)-methyladenosine (m(6)A) modification balance and influences a variety of cancers. We tested whether YTHDF2 gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However, the rs3738067 A>G polymorphism showed no statistical significance with Wilms tumor susceptibility. Stratification analysis also revealed that there was no remarkable association of rs3738067 variant AG/GG genotype with Wilms tumor risk in every subgroup (age, gender, and clinical stages). In all, the results indicated YTHDF2 gene rs3738067 A>G polymorphism could not alter Wilms tumor risk significantly. Ivyspring International Publisher 2021-08-26 /pmc/articles/PMC8425210/ /pubmed/34539889 http://dx.doi.org/10.7150/jca.62154 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Zhiyuan
Zhuo, Zhenjian
Li, Linyan
Hua, Rui-Xi
Li, Li
Zhang, Jiao
Cheng, Jiwen
Zhou, Haixia
Li, Suhong
He, Jing
Yan, Shan
The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title_full The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title_fullStr The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title_full_unstemmed The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title_short The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility
title_sort contribution of ythdf2 gene rs3738067 a>g to the wilms tumor susceptibility
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425210/
https://www.ncbi.nlm.nih.gov/pubmed/34539889
http://dx.doi.org/10.7150/jca.62154
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