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Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents

INTRODUCTION: In recent years hypertension has become an emerging condition in the young population. It has been proposed that the renin–angiotensin system plays an important role in regulation of blood pressure. We assessed whether activation of the intrarenal renin-angiotensin system occurs in hyp...

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Autores principales: Zając, Magdalena, Rybi-Szumińska, Agnieszka, Storonowicz, Justyna, Protas, Piotr, Wasilewska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425233/
https://www.ncbi.nlm.nih.gov/pubmed/34522262
http://dx.doi.org/10.5114/aoms.2019.88482
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author Zając, Magdalena
Rybi-Szumińska, Agnieszka
Storonowicz, Justyna
Protas, Piotr
Wasilewska, Anna
author_facet Zając, Magdalena
Rybi-Szumińska, Agnieszka
Storonowicz, Justyna
Protas, Piotr
Wasilewska, Anna
author_sort Zając, Magdalena
collection PubMed
description INTRODUCTION: In recent years hypertension has become an emerging condition in the young population. It has been proposed that the renin–angiotensin system plays an important role in regulation of blood pressure. We assessed whether activation of the intrarenal renin-angiotensin system occurs in hypertensive children and adolescents and what better reflects its activity: urine angiotensinogen (AGT) or urine renin (REN). MATERIAL AND METHODS: The study was conducted on a sample of 58 subjects with primary hypertension (HT) and 29 normotensive children and adolescents. We measured urine REN and AGT excretion and assessed the values in relation to blood pressure (BP) and other clinical parameters. Both REN and AGT values were calculated by urine creatinine: REN/cr. and AGT/cr., respectively. RESULTS: We observed higher urine REN/cr. values in hypertensive subjects in comparison to the reference group (6.99 vs. 2.93, p = 0.003). Hypertensive participants showed positive correlations between urine REN/cr. and diastolic 24-hour BP (r = 0.42, p = 0.002) as well as between urine REN/cr. and urine AGT/cr. (r = 0.266, p = 0.044, respectively). CONCLUSIONS: Increased urine REN/cr. in hypertensive children and adolescents and its positive correlation with BP may indicate its important role in the pathogenesis of HT. Perhaps urine REN/cr. could be a marker of intrarenal renin-angiotensin system activity. Nevertheless, further research should be undertaken to confirm this observation.
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spelling pubmed-84252332021-09-13 Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents Zając, Magdalena Rybi-Szumińska, Agnieszka Storonowicz, Justyna Protas, Piotr Wasilewska, Anna Arch Med Sci Clinical Research INTRODUCTION: In recent years hypertension has become an emerging condition in the young population. It has been proposed that the renin–angiotensin system plays an important role in regulation of blood pressure. We assessed whether activation of the intrarenal renin-angiotensin system occurs in hypertensive children and adolescents and what better reflects its activity: urine angiotensinogen (AGT) or urine renin (REN). MATERIAL AND METHODS: The study was conducted on a sample of 58 subjects with primary hypertension (HT) and 29 normotensive children and adolescents. We measured urine REN and AGT excretion and assessed the values in relation to blood pressure (BP) and other clinical parameters. Both REN and AGT values were calculated by urine creatinine: REN/cr. and AGT/cr., respectively. RESULTS: We observed higher urine REN/cr. values in hypertensive subjects in comparison to the reference group (6.99 vs. 2.93, p = 0.003). Hypertensive participants showed positive correlations between urine REN/cr. and diastolic 24-hour BP (r = 0.42, p = 0.002) as well as between urine REN/cr. and urine AGT/cr. (r = 0.266, p = 0.044, respectively). CONCLUSIONS: Increased urine REN/cr. in hypertensive children and adolescents and its positive correlation with BP may indicate its important role in the pathogenesis of HT. Perhaps urine REN/cr. could be a marker of intrarenal renin-angiotensin system activity. Nevertheless, further research should be undertaken to confirm this observation. Termedia Publishing House 2019-10-07 /pmc/articles/PMC8425233/ /pubmed/34522262 http://dx.doi.org/10.5114/aoms.2019.88482 Text en Copyright: © 2019 Termedia & Banach https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Zając, Magdalena
Rybi-Szumińska, Agnieszka
Storonowicz, Justyna
Protas, Piotr
Wasilewska, Anna
Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title_full Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title_fullStr Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title_full_unstemmed Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title_short Urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
title_sort urinary excretion of renin and angiotensinogen in hypertensive children and adolescents
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425233/
https://www.ncbi.nlm.nih.gov/pubmed/34522262
http://dx.doi.org/10.5114/aoms.2019.88482
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