Serum negative neuromyelitis optica spectrum disorder after vaxzevria vaccination: A case report

BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease, targeting the central nervous system, rarely associated with vaccination. CASE REPORT: We report a case of a 47 year-old healthy woman who presented, ten days after the first dose of SARS-CoV-2 Vaccine AstraZene...

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Detalles Bibliográficos
Autores principales: Gorgone, Gaetano, Giudice, Francesco Del, David, Piero, Franco, Giovanni, Giofrè, Laura, Grillo, Gaetano, Iellamo, Mattia Anna, Mastrandrea, Carmela, Orlando, Concetta, Vecchio, Antonino, Galati, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425290/
http://dx.doi.org/10.1016/j.nerep.2021.100016
Descripción
Sumario:BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease, targeting the central nervous system, rarely associated with vaccination. CASE REPORT: We report a case of a 47 year-old healthy woman who presented, ten days after the first dose of SARS-CoV-2 Vaccine AstraZeneca (Vaxzevria), with back pain, tetraplegia, urinary retention, dysarthria and dysphagia. The patient was diagnosed NMOSD. She underwent intravenous-corticosteroids, vein-Immunoglobulin and plasma-exchange without significant improvement . CONCLUSION: The absence of any possible related conditions, the temporal relation with anti-SARS-CoV-2 vaccination, suggest that, in our case, NMOSD may be due to the cross reaction from Vaxzevria.

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