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Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis

Air pollution is a serious threat to our health and has become one of the major causes of many diseases including cardiovascular disease, respiratory disease, and cancer. The association between air pollution and various diseases has long been a topic of research interest. However, it remains unclea...

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Autores principales: Mukherjee, Suranjana, Dasgupta, Sanjukta, Mishra, Pradyumna K., Chaudhury, Koel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425320/
https://www.ncbi.nlm.nih.gov/pubmed/34498177
http://dx.doi.org/10.1007/s11356-021-16056-x
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author Mukherjee, Suranjana
Dasgupta, Sanjukta
Mishra, Pradyumna K.
Chaudhury, Koel
author_facet Mukherjee, Suranjana
Dasgupta, Sanjukta
Mishra, Pradyumna K.
Chaudhury, Koel
author_sort Mukherjee, Suranjana
collection PubMed
description Air pollution is a serious threat to our health and has become one of the major causes of many diseases including cardiovascular disease, respiratory disease, and cancer. The association between air pollution and various diseases has long been a topic of research interest. However, it remains unclear how air pollution actually impacts health by modulating several important cellular functions. Recently, some evidence has emerged about air pollution-induced epigenetic changes, which are linked with the etiology of various human diseases. Among several epigenetic modifications, DNA methylation represents the most prominent epigenetic alteration underlying the air pollution-induced pathogenic mechanism. Several other types of epigenetic changes, such as histone modifications, miRNA, and non-coding RNA expression, have also been found to have been linked with air pollution. Hypersensitivity pneumonitis (HP), one of the most prevalent forms of interstitial lung diseases (ILDs), is triggered by the inhalation of certain organic and inorganic substances. HP is characterized by inflammation in the tissues around the lungs’ airways and may lead to irreversible lung scarring over time. This review, in addition to other diseases, attempts to understand whether certain pollutants influence HP development through such epigenetic modifications.
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spelling pubmed-84253202021-09-09 Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis Mukherjee, Suranjana Dasgupta, Sanjukta Mishra, Pradyumna K. Chaudhury, Koel Environ Sci Pollut Res Int Review Article Air pollution is a serious threat to our health and has become one of the major causes of many diseases including cardiovascular disease, respiratory disease, and cancer. The association between air pollution and various diseases has long been a topic of research interest. However, it remains unclear how air pollution actually impacts health by modulating several important cellular functions. Recently, some evidence has emerged about air pollution-induced epigenetic changes, which are linked with the etiology of various human diseases. Among several epigenetic modifications, DNA methylation represents the most prominent epigenetic alteration underlying the air pollution-induced pathogenic mechanism. Several other types of epigenetic changes, such as histone modifications, miRNA, and non-coding RNA expression, have also been found to have been linked with air pollution. Hypersensitivity pneumonitis (HP), one of the most prevalent forms of interstitial lung diseases (ILDs), is triggered by the inhalation of certain organic and inorganic substances. HP is characterized by inflammation in the tissues around the lungs’ airways and may lead to irreversible lung scarring over time. This review, in addition to other diseases, attempts to understand whether certain pollutants influence HP development through such epigenetic modifications. Springer Berlin Heidelberg 2021-09-08 2021 /pmc/articles/PMC8425320/ /pubmed/34498177 http://dx.doi.org/10.1007/s11356-021-16056-x Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Mukherjee, Suranjana
Dasgupta, Sanjukta
Mishra, Pradyumna K.
Chaudhury, Koel
Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title_full Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title_fullStr Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title_full_unstemmed Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title_short Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
title_sort air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425320/
https://www.ncbi.nlm.nih.gov/pubmed/34498177
http://dx.doi.org/10.1007/s11356-021-16056-x
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