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Gut microbiota alterations in response to sleep length among African-origin adults
Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425534/ https://www.ncbi.nlm.nih.gov/pubmed/34495955 http://dx.doi.org/10.1371/journal.pone.0255323 |
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author | Fei, Na Choo-Kang, Candice Reutrakul, Sirimon Crowley, Stephanie J. Rae, Dale Bedu-Addo, Kweku Plange-Rhule, Jacob Forrester, Terrence E. Lambert, Estelle V. Bovet, Pascal Riesen, Walter Korte, Wolfgang Luke, Amy Layden, Brian T. Gilbert, Jack A. Dugas, Lara R. |
author_facet | Fei, Na Choo-Kang, Candice Reutrakul, Sirimon Crowley, Stephanie J. Rae, Dale Bedu-Addo, Kweku Plange-Rhule, Jacob Forrester, Terrence E. Lambert, Estelle V. Bovet, Pascal Riesen, Walter Korte, Wolfgang Luke, Amy Layden, Brian T. Gilbert, Jack A. Dugas, Lara R. |
author_sort | Fei, Na |
collection | PubMed |
description | Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on the gut microbiota in a large cohort of 655 participants of African descent, aged 25–45, from Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was self-reported via a questionnaire. Participants were classified into 3 sleep groups: short (<7hrs), normal (7-<9hrs), and long (≥9hrs). Forty-seven percent of US participants were classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively correlated with sleep length (p<0.05). Furthermore, sleep length significantly contributed to the inter-individual beta diversity dissimilarity in gut microbial composition (p<0.01). Participants with both short and long-sleep durations exhibited significantly higher abundances of several taxonomic features, compared to normal sleep duration participants. The predicted relative proportion of two genes involved in the butyrate synthesis via lysine pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships revealed by network analysis showed unique interactions among the short, normal and long duration sleepers. These results suggest that sleep length in humans may alter gut microbiota by driving population shifts of the whole microbiota and also specific changes in Exact Sequence Variants abundance, which may have implications for chronic inflammation associated diseases. The current findings suggest a possible relationship between disrupted sleep patterns and the composition of the gut microbiota. Prospective investigations in larger and more prolonged sleep researches and causally experimental studies are needed to confirm these findings, investigate the underlying mechanism and determine whether improving microbial homeostasis may buffer against sleep-related health decline in humans. |
format | Online Article Text |
id | pubmed-8425534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-84255342021-09-09 Gut microbiota alterations in response to sleep length among African-origin adults Fei, Na Choo-Kang, Candice Reutrakul, Sirimon Crowley, Stephanie J. Rae, Dale Bedu-Addo, Kweku Plange-Rhule, Jacob Forrester, Terrence E. Lambert, Estelle V. Bovet, Pascal Riesen, Walter Korte, Wolfgang Luke, Amy Layden, Brian T. Gilbert, Jack A. Dugas, Lara R. PLoS One Research Article Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on the gut microbiota in a large cohort of 655 participants of African descent, aged 25–45, from Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was self-reported via a questionnaire. Participants were classified into 3 sleep groups: short (<7hrs), normal (7-<9hrs), and long (≥9hrs). Forty-seven percent of US participants were classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively correlated with sleep length (p<0.05). Furthermore, sleep length significantly contributed to the inter-individual beta diversity dissimilarity in gut microbial composition (p<0.01). Participants with both short and long-sleep durations exhibited significantly higher abundances of several taxonomic features, compared to normal sleep duration participants. The predicted relative proportion of two genes involved in the butyrate synthesis via lysine pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships revealed by network analysis showed unique interactions among the short, normal and long duration sleepers. These results suggest that sleep length in humans may alter gut microbiota by driving population shifts of the whole microbiota and also specific changes in Exact Sequence Variants abundance, which may have implications for chronic inflammation associated diseases. The current findings suggest a possible relationship between disrupted sleep patterns and the composition of the gut microbiota. Prospective investigations in larger and more prolonged sleep researches and causally experimental studies are needed to confirm these findings, investigate the underlying mechanism and determine whether improving microbial homeostasis may buffer against sleep-related health decline in humans. Public Library of Science 2021-09-08 /pmc/articles/PMC8425534/ /pubmed/34495955 http://dx.doi.org/10.1371/journal.pone.0255323 Text en © 2021 Fei et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fei, Na Choo-Kang, Candice Reutrakul, Sirimon Crowley, Stephanie J. Rae, Dale Bedu-Addo, Kweku Plange-Rhule, Jacob Forrester, Terrence E. Lambert, Estelle V. Bovet, Pascal Riesen, Walter Korte, Wolfgang Luke, Amy Layden, Brian T. Gilbert, Jack A. Dugas, Lara R. Gut microbiota alterations in response to sleep length among African-origin adults |
title | Gut microbiota alterations in response to sleep length among African-origin adults |
title_full | Gut microbiota alterations in response to sleep length among African-origin adults |
title_fullStr | Gut microbiota alterations in response to sleep length among African-origin adults |
title_full_unstemmed | Gut microbiota alterations in response to sleep length among African-origin adults |
title_short | Gut microbiota alterations in response to sleep length among African-origin adults |
title_sort | gut microbiota alterations in response to sleep length among african-origin adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425534/ https://www.ncbi.nlm.nih.gov/pubmed/34495955 http://dx.doi.org/10.1371/journal.pone.0255323 |
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