A three-antigen Plasmodium falciparum DNA prime—Adenovirus boost malaria vaccine regimen is superior to a two-antigen regimen and protects against controlled human malaria infection in healthy malaria-naïve adults

BACKGROUND: A DNA-prime/human adenovirus serotype 5 (HuAd5) boost vaccine encoding Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) and Pf apical membrane antigen-1 (PfAMA1), elicited protection in 4/15 (27%) of subjects against controlled human malaria infection (CHMI) that was statistic...

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Autores principales: Sklar, Marvin J., Maiolatesi, Santina, Patterson, Noelle, Sedegah, Martha, Limbach, Keith, Teneza-Mora, Nimfa, Chuang, Ilin, Hollis-Perry, K. Monique, Banania, Jo Glenna, Guzman, Ivelese, Ganeshan, Harini, Reyes, Sharina, Hollingdale, Michael R., Wong, Mimi, Lindstrom, Ashley, Reyes, Anatalio, Alcorta, Yolanda, Garver, Lindsey, Bankard, Kelli, Belmonte, Arnel, Belmonte, Maria, Huang, Jun, Gowda, Kalpana, Inoue, Sandra, Velasco, Rachel, Bergmann-Leitner, Elke, Hutter, Jack, Lee, Tida, Adams, Nehkonti, Chaudhury, Sidhartha, Hunt, Devin, Tamminga, Cindy, Berrie, Eleanor, Bellamy, Duncan, Bittaye, Mustapha, Ewer, Katie, Diggs, Carter, Soisson, Lorraine A., Lawrie, Alison, Hill, Adrian, Richie, Thomas L., Villasante, Eileen, Epstein, Judith E., Duplessis, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425539/
https://www.ncbi.nlm.nih.gov/pubmed/34495988
http://dx.doi.org/10.1371/journal.pone.0256980

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