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Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects

Childhood obesity and T2DM have shown a recent alarming increase due to important changes in global lifestyle and dietary habits, highlighting the need for urgent and novel solutions to improve global public health. Gut microbiota has been shown to be relevant in human health and its dysbiosis has b...

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Autores principales: Carrizales-Sánchez, Ana K., García-Cayuela, Tomás, Hernández-Brenes, Carmen, Senés-Guerrero, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425709/
https://www.ncbi.nlm.nih.gov/pubmed/34491882
http://dx.doi.org/10.1080/19490976.2021.1960135
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author Carrizales-Sánchez, Ana K.
García-Cayuela, Tomás
Hernández-Brenes, Carmen
Senés-Guerrero, Carolina
author_facet Carrizales-Sánchez, Ana K.
García-Cayuela, Tomás
Hernández-Brenes, Carmen
Senés-Guerrero, Carolina
author_sort Carrizales-Sánchez, Ana K.
collection PubMed
description Childhood obesity and T2DM have shown a recent alarming increase due to important changes in global lifestyle and dietary habits, highlighting the need for urgent and novel solutions to improve global public health. Gut microbiota has been shown to be relevant in human health and its dysbiosis has been associated with MetS, a health condition linked to the onset of relevant diseases including T2DM. Even though there have been recent improvements in the understanding of gut microbiota–host interactions, pediatric gut microbiota has been poorly studied compared to adults. This review provides an overview of MetS and its relevance in school-age children, discusses gut microbiota and its possible association with this metabolic condition including relevant emerging gut microbiome-based interventions for its prevention and treatment, and outlines future challenges and perspectives in preventing microbiota dysbiosis from the early stages of life.
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spelling pubmed-84257092021-09-09 Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects Carrizales-Sánchez, Ana K. García-Cayuela, Tomás Hernández-Brenes, Carmen Senés-Guerrero, Carolina Gut Microbes Review Childhood obesity and T2DM have shown a recent alarming increase due to important changes in global lifestyle and dietary habits, highlighting the need for urgent and novel solutions to improve global public health. Gut microbiota has been shown to be relevant in human health and its dysbiosis has been associated with MetS, a health condition linked to the onset of relevant diseases including T2DM. Even though there have been recent improvements in the understanding of gut microbiota–host interactions, pediatric gut microbiota has been poorly studied compared to adults. This review provides an overview of MetS and its relevance in school-age children, discusses gut microbiota and its possible association with this metabolic condition including relevant emerging gut microbiome-based interventions for its prevention and treatment, and outlines future challenges and perspectives in preventing microbiota dysbiosis from the early stages of life. Taylor & Francis 2021-09-07 /pmc/articles/PMC8425709/ /pubmed/34491882 http://dx.doi.org/10.1080/19490976.2021.1960135 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Carrizales-Sánchez, Ana K.
García-Cayuela, Tomás
Hernández-Brenes, Carmen
Senés-Guerrero, Carolina
Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title_full Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title_fullStr Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title_full_unstemmed Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title_short Gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
title_sort gut microbiota associations with metabolic syndrome and relevance of its study in pediatric subjects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425709/
https://www.ncbi.nlm.nih.gov/pubmed/34491882
http://dx.doi.org/10.1080/19490976.2021.1960135
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