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Effects of Age on Esophageal Motility: A High-Resolution Manometry Study

BACKGROUND: Studies have found possible physiologic changes to esophageal motility with aging currently not taken into account in routine high-resolution manometry (HRM) interpretation. We aimed to quantify the relationship between these physiologic changes and aging to improve HRM interpretation. M...

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Autores principales: Djinbachian, Roupen, Marchand, Etienne, Yan, Weixiang, Bouin, Mickael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425793/
https://www.ncbi.nlm.nih.gov/pubmed/34527096
http://dx.doi.org/10.14740/jocmr4576
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author Djinbachian, Roupen
Marchand, Etienne
Yan, Weixiang
Bouin, Mickael
author_facet Djinbachian, Roupen
Marchand, Etienne
Yan, Weixiang
Bouin, Mickael
author_sort Djinbachian, Roupen
collection PubMed
description BACKGROUND: Studies have found possible physiologic changes to esophageal motility with aging currently not taken into account in routine high-resolution manometry (HRM) interpretation. We aimed to quantify the relationship between these physiologic changes and aging to improve HRM interpretation. METHODS: We conducted a retrospective analysis of patients who underwent HRM at a tertiary hospital center between 2015 and 2019. Inclusion criteria were patients aged ≥18 years with normal HRM. Exclusion criteria were abnormal HRM, abnormal upper digestive endoscopy or imagery. Outcomes were median integrated relaxation pressure (IRP), lower esophageal sphincter (LES) pressure, distal contractal integral (DCI), distal latency (DL), and peristaltic break (PB) according to the v4.0 Chicago classification criteria. Effect of age was examined through univariate and multivariate linear regression analysis. RESULTS: We identified 1,917 patients with HRM and included 722 patients with normal exams (median age 56 years (interquartile range (IQR) 46 - 66), 63.8% female). Indications for HRM included dysphagia (39.6%), gastroesophageal reflux disease (29.5%), and chest pain (11.5%). There was statistically significant relationship between age and IRP (r = 0.20, P < 0.0001) as well as DCI (r = 0.12, P = 0.001) and DL (r = -0.09, P = 0.02). No statistically significant relationship was found between age and LES pressure or PB. CONCLUSION: We found that IRP, DCI, and to a lesser extent, DL, are significantly correlated with the normal aging process in symptomatic patients. These findings should be taken into consideration when interpreting esophageal HRM.
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spelling pubmed-84257932021-09-14 Effects of Age on Esophageal Motility: A High-Resolution Manometry Study Djinbachian, Roupen Marchand, Etienne Yan, Weixiang Bouin, Mickael J Clin Med Res Original Article BACKGROUND: Studies have found possible physiologic changes to esophageal motility with aging currently not taken into account in routine high-resolution manometry (HRM) interpretation. We aimed to quantify the relationship between these physiologic changes and aging to improve HRM interpretation. METHODS: We conducted a retrospective analysis of patients who underwent HRM at a tertiary hospital center between 2015 and 2019. Inclusion criteria were patients aged ≥18 years with normal HRM. Exclusion criteria were abnormal HRM, abnormal upper digestive endoscopy or imagery. Outcomes were median integrated relaxation pressure (IRP), lower esophageal sphincter (LES) pressure, distal contractal integral (DCI), distal latency (DL), and peristaltic break (PB) according to the v4.0 Chicago classification criteria. Effect of age was examined through univariate and multivariate linear regression analysis. RESULTS: We identified 1,917 patients with HRM and included 722 patients with normal exams (median age 56 years (interquartile range (IQR) 46 - 66), 63.8% female). Indications for HRM included dysphagia (39.6%), gastroesophageal reflux disease (29.5%), and chest pain (11.5%). There was statistically significant relationship between age and IRP (r = 0.20, P < 0.0001) as well as DCI (r = 0.12, P = 0.001) and DL (r = -0.09, P = 0.02). No statistically significant relationship was found between age and LES pressure or PB. CONCLUSION: We found that IRP, DCI, and to a lesser extent, DL, are significantly correlated with the normal aging process in symptomatic patients. These findings should be taken into consideration when interpreting esophageal HRM. Elmer Press 2021-08 2021-08-30 /pmc/articles/PMC8425793/ /pubmed/34527096 http://dx.doi.org/10.14740/jocmr4576 Text en Copyright 2021, Djinbachian et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Djinbachian, Roupen
Marchand, Etienne
Yan, Weixiang
Bouin, Mickael
Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title_full Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title_fullStr Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title_full_unstemmed Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title_short Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
title_sort effects of age on esophageal motility: a high-resolution manometry study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425793/
https://www.ncbi.nlm.nih.gov/pubmed/34527096
http://dx.doi.org/10.14740/jocmr4576
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