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HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors
Tumor microenvironment‐responsive nanodrugs offer promising opportunities for imaging‐guided precision therapy with reduced side effects. Considering that the antitumor effect is closely related to the size of the nanodrugs, it is particularly important to develop a therapeutic system with size adju...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425924/ https://www.ncbi.nlm.nih.gov/pubmed/34235882 http://dx.doi.org/10.1002/advs.202100074 |
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author | Liu, Dongya Liu, Lingyan Liu, Feiyang Zhang, Mengfan Wei, Peng Yi, Tao |
author_facet | Liu, Dongya Liu, Lingyan Liu, Feiyang Zhang, Mengfan Wei, Peng Yi, Tao |
author_sort | Liu, Dongya |
collection | PubMed |
description | Tumor microenvironment‐responsive nanodrugs offer promising opportunities for imaging‐guided precision therapy with reduced side effects. Considering that the antitumor effect is closely related to the size of the nanodrugs, it is particularly important to develop a therapeutic system with size adjustability in the tumor microenvironment, which is still a great challenge in the field of nanotheranostics. Herein, a reactive oxygen species (ROS)‐activated aggregation strategy is reported for imaging‐guided precision therapy of tumors. The ROS‐activated nanoplatform is constructed based on gold nanoparticles (AuNPs) coated with an HOCl probe on its surface (namely, Au–MB–PEG NPs). The Au–MB–PEG NPs show high sensitivity toward HOCl, resulting in the modulation of surface charge and rapid aggregation of AuNPs, and simultaneous release of methylene blue as a photosensitizer for photodynamic therapy (PDT). In the tumor environment, the aggregated AuNPs ensure higher tumor accumulation and retention. Furthermore, the redshift of the absorption of aggregated AuNPs leads to activated photoacoustic imaging signals and photothermal therapy (PTT) under near‐infrared irradiation. Au–MB–PEG NPs thus efficiently inhibit the tumor growth through combined PTT–PDT therapy. This work contributes to the design of stimuli‐induced size‐aggregation nanodrugs, thereby attaining advanced performance in cancer diagnosis and treatment. |
format | Online Article Text |
id | pubmed-8425924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84259242021-09-13 HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors Liu, Dongya Liu, Lingyan Liu, Feiyang Zhang, Mengfan Wei, Peng Yi, Tao Adv Sci (Weinh) Research Articles Tumor microenvironment‐responsive nanodrugs offer promising opportunities for imaging‐guided precision therapy with reduced side effects. Considering that the antitumor effect is closely related to the size of the nanodrugs, it is particularly important to develop a therapeutic system with size adjustability in the tumor microenvironment, which is still a great challenge in the field of nanotheranostics. Herein, a reactive oxygen species (ROS)‐activated aggregation strategy is reported for imaging‐guided precision therapy of tumors. The ROS‐activated nanoplatform is constructed based on gold nanoparticles (AuNPs) coated with an HOCl probe on its surface (namely, Au–MB–PEG NPs). The Au–MB–PEG NPs show high sensitivity toward HOCl, resulting in the modulation of surface charge and rapid aggregation of AuNPs, and simultaneous release of methylene blue as a photosensitizer for photodynamic therapy (PDT). In the tumor environment, the aggregated AuNPs ensure higher tumor accumulation and retention. Furthermore, the redshift of the absorption of aggregated AuNPs leads to activated photoacoustic imaging signals and photothermal therapy (PTT) under near‐infrared irradiation. Au–MB–PEG NPs thus efficiently inhibit the tumor growth through combined PTT–PDT therapy. This work contributes to the design of stimuli‐induced size‐aggregation nanodrugs, thereby attaining advanced performance in cancer diagnosis and treatment. John Wiley and Sons Inc. 2021-07-08 /pmc/articles/PMC8425924/ /pubmed/34235882 http://dx.doi.org/10.1002/advs.202100074 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Liu, Dongya Liu, Lingyan Liu, Feiyang Zhang, Mengfan Wei, Peng Yi, Tao HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title | HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title_full | HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title_fullStr | HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title_full_unstemmed | HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title_short | HOCl‐Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors |
title_sort | hocl‐activated aggregation of gold nanoparticles for multimodality therapy of tumors |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425924/ https://www.ncbi.nlm.nih.gov/pubmed/34235882 http://dx.doi.org/10.1002/advs.202100074 |
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