Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

Maternal loss of imprinting (LOI) at the H19/IGF2 locus results in biallelic IGF2 and reduced H19 expression and is associated with Beckwith–-Wiedemann syndrome (BWS). We use mouse models for LOI to understand the relative importance of Igf2 and H19 mis-expression in BWS phenotypes. Here we focus on...

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Detalles Bibliográficos
Autores principales: Park, Ki-Sun, Rahat, Beenish, Lee, Hyung Chul, Yu, Zu-Xi, Noeker, Jacob, Mitra, Apratim, Kean, Connor M, Knutsen, Russell H, Springer, Danielle, Gebert, Claudia M, Kozel, Beth A, Pfeifer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425947/
https://www.ncbi.nlm.nih.gov/pubmed/34402430
http://dx.doi.org/10.7554/eLife.67250

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