Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa

Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects in multiple zebrafish and mouse RP models, reason...

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Detalles Bibliográficos
Autores principales: Zhang, Liyun, Chen, Conan, Fu, Jie, Lilley, Brendan, Berlinicke, Cynthia, Hansen, Baranda, Ding, Ding, Wang, Guohua, Wang, Tao, Shou, Daniel, Ye, Ying, Mulligan, Timothy, Emmerich, Kevin, Saxena, Meera T, Hall, Kelsi R, Sharrock, Abigail V, Brandon, Carlene, Park, Hyejin, Kam, Tae-In, Dawson, Valina L, Dawson, Ted M, Shim, Joong Sup, Hanes, Justin, Ji, Hongkai, Liu, Jun O, Qian, Jiang, Ackerley, David F, Rohrer, Baerbel, Zack, Donald J, Mumm, Jeff S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425951/
https://www.ncbi.nlm.nih.gov/pubmed/34184634
http://dx.doi.org/10.7554/eLife.57245

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