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Divergence in Population Coding for Space between Dorsal and Ventral CA1

Molecular, anatomic, and behavioral studies show that the hippocampus is structurally and functionally heterogeneous, with dorsal hippocampus implicated in mnemonic processes and spatial navigation and ventral hippocampus involved in affective processes. By performing electrophysiological recordings...

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Autores principales: Chockanathan, Udaysankar, Padmanabhan, Krishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425966/
https://www.ncbi.nlm.nih.gov/pubmed/34433573
http://dx.doi.org/10.1523/ENEURO.0211-21.2021
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author Chockanathan, Udaysankar
Padmanabhan, Krishnan
author_facet Chockanathan, Udaysankar
Padmanabhan, Krishnan
author_sort Chockanathan, Udaysankar
collection PubMed
description Molecular, anatomic, and behavioral studies show that the hippocampus is structurally and functionally heterogeneous, with dorsal hippocampus implicated in mnemonic processes and spatial navigation and ventral hippocampus involved in affective processes. By performing electrophysiological recordings of large neuronal populations in dorsal and ventral CA1 in head-fixed mice navigating a virtual environment, we found that this diversity resulted in different strategies for population coding of space. Populations of neurons in dorsal CA1 showed more complex patterns of activity, which resulted in a higher dimensionality of neural representations that translated to more information being encoded, as compared ensembles in vCA1. Furthermore, a pairwise maximum entropy model was better at predicting the structure of these global patterns of activity in ventral CA1 as compared with dorsal CA1. Taken together, the different coding strategies we uncovered likely emerge from anatomic and physiological differences along the longitudinal axis of hippocampus and that may, in turn, underpin the divergent ethological roles of dorsal and ventral CA1.
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spelling pubmed-84259662021-09-09 Divergence in Population Coding for Space between Dorsal and Ventral CA1 Chockanathan, Udaysankar Padmanabhan, Krishnan eNeuro Research Article: New Research Molecular, anatomic, and behavioral studies show that the hippocampus is structurally and functionally heterogeneous, with dorsal hippocampus implicated in mnemonic processes and spatial navigation and ventral hippocampus involved in affective processes. By performing electrophysiological recordings of large neuronal populations in dorsal and ventral CA1 in head-fixed mice navigating a virtual environment, we found that this diversity resulted in different strategies for population coding of space. Populations of neurons in dorsal CA1 showed more complex patterns of activity, which resulted in a higher dimensionality of neural representations that translated to more information being encoded, as compared ensembles in vCA1. Furthermore, a pairwise maximum entropy model was better at predicting the structure of these global patterns of activity in ventral CA1 as compared with dorsal CA1. Taken together, the different coding strategies we uncovered likely emerge from anatomic and physiological differences along the longitudinal axis of hippocampus and that may, in turn, underpin the divergent ethological roles of dorsal and ventral CA1. Society for Neuroscience 2021-09-07 /pmc/articles/PMC8425966/ /pubmed/34433573 http://dx.doi.org/10.1523/ENEURO.0211-21.2021 Text en Copyright © 2021 Chockanathan and Padmanabhan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Chockanathan, Udaysankar
Padmanabhan, Krishnan
Divergence in Population Coding for Space between Dorsal and Ventral CA1
title Divergence in Population Coding for Space between Dorsal and Ventral CA1
title_full Divergence in Population Coding for Space between Dorsal and Ventral CA1
title_fullStr Divergence in Population Coding for Space between Dorsal and Ventral CA1
title_full_unstemmed Divergence in Population Coding for Space between Dorsal and Ventral CA1
title_short Divergence in Population Coding for Space between Dorsal and Ventral CA1
title_sort divergence in population coding for space between dorsal and ventral ca1
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425966/
https://www.ncbi.nlm.nih.gov/pubmed/34433573
http://dx.doi.org/10.1523/ENEURO.0211-21.2021
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