Antimicrobial peptides: mechanism of action, activity and clinical potential

The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a...

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Autores principales: Zhang, Qi-Yu, Yan, Zhi-Bin, Meng, Yue-Ming, Hong, Xiang-Yu, Shao, Gang, Ma, Jun-Jie, Cheng, Xu-Rui, Liu, Jun, Kang, Jian, Fu, Cai-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425997/
https://www.ncbi.nlm.nih.gov/pubmed/34496967
http://dx.doi.org/10.1186/s40779-021-00343-2
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author Zhang, Qi-Yu
Yan, Zhi-Bin
Meng, Yue-Ming
Hong, Xiang-Yu
Shao, Gang
Ma, Jun-Jie
Cheng, Xu-Rui
Liu, Jun
Kang, Jian
Fu, Cai-Yun
author_facet Zhang, Qi-Yu
Yan, Zhi-Bin
Meng, Yue-Ming
Hong, Xiang-Yu
Shao, Gang
Ma, Jun-Jie
Cheng, Xu-Rui
Liu, Jun
Kang, Jian
Fu, Cai-Yun
author_sort Zhang, Qi-Yu
collection PubMed
description The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00343-2.
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spelling pubmed-84259972021-09-09 Antimicrobial peptides: mechanism of action, activity and clinical potential Zhang, Qi-Yu Yan, Zhi-Bin Meng, Yue-Ming Hong, Xiang-Yu Shao, Gang Ma, Jun-Jie Cheng, Xu-Rui Liu, Jun Kang, Jian Fu, Cai-Yun Mil Med Res Review The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40779-021-00343-2. BioMed Central 2021-09-09 /pmc/articles/PMC8425997/ /pubmed/34496967 http://dx.doi.org/10.1186/s40779-021-00343-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Qi-Yu
Yan, Zhi-Bin
Meng, Yue-Ming
Hong, Xiang-Yu
Shao, Gang
Ma, Jun-Jie
Cheng, Xu-Rui
Liu, Jun
Kang, Jian
Fu, Cai-Yun
Antimicrobial peptides: mechanism of action, activity and clinical potential
title Antimicrobial peptides: mechanism of action, activity and clinical potential
title_full Antimicrobial peptides: mechanism of action, activity and clinical potential
title_fullStr Antimicrobial peptides: mechanism of action, activity and clinical potential
title_full_unstemmed Antimicrobial peptides: mechanism of action, activity and clinical potential
title_short Antimicrobial peptides: mechanism of action, activity and clinical potential
title_sort antimicrobial peptides: mechanism of action, activity and clinical potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425997/
https://www.ncbi.nlm.nih.gov/pubmed/34496967
http://dx.doi.org/10.1186/s40779-021-00343-2
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