Cargando…

Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies

Drug repurposing is an important approach to the assignment of already approved drugs for new indications. This technique bypasses some steps in the traditional drug approval system, which saves time and lives in the case of pandemics. Direct acting antivirals (DAAs) have repeatedly repurposed from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahmoud, Amal, Mostafa, Ahmed, Al-Karmalawy, Ahmed A., Zidan, Ahmad, Abulkhair, Hamada S., Mahmoud, Sara H., Shehata, Mahmoud, Elhefnawi, Mahmoud M., Ali, Mohamed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426143/ https://www.ncbi.nlm.nih.gov/pubmed/34518806 http://dx.doi.org/10.1016/j.heliyon.2021.e07962

Ejemplares similares

In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate Vaccine
por: Shehata, Mahmoud M., et al.
Publicado: (2021)

Robust antiviral activity of commonly prescribed antidepressants against emerging coronaviruses: in vitro and in silico drug repurposing studies
por: Kutkat, Omnia, et al.
Publicado: (2022)

Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2
por: Al-Karmalawy, Ahmed A., et al.
Publicado: (2021)

Targeting SARS-CoV-2 endoribonuclease: a structure-based virtual screening supported by in vitro analysis
por: Ibrahim, Ibrahim M., et al.
Publicado: (2022)

Progress, pitfalls, and path forward of drug repurposing for COVID-19 treatment
por: Taibe, Noha Samir, et al.
Publicado: (2022)

In vitro and computational investigations of novel synthetic carboxamide-linked pyridopyrrolopyrimidines with potent activity as SARS-CoV-2-M(Pro) inhibitors
por: Aljuhani, Ateyatallah, et al.
Publicado: (2022)

β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization
por: Hamed, Mohammed I. A., et al.
Publicado: (2021)

Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome
por: El-aarag, Salem A., et al.
Publicado: (2022)

Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?
por: Mahmoud, Dina B., et al.
Publicado: (2020)

Pimenta dioica (L.) Merr. Bioactive Constituents Exert Anti-SARS-CoV-2 and Anti-Inflammatory Activities: Molecular Docking and Dynamics, In Vitro, and In Vivo Studies
por: El Gizawy, Heba A., et al.
Publicado: (2021)

Telaprevir
Publicado: (2012)

Coding-Complete Genome Sequences of Two SARS-CoV-2 Isolates from Egypt
por: Kandeil, Ahmed, et al.
Publicado: (2020)

In-Silico targeting of SARS-CoV-2 NSP6 for drug and natural products repurposing
por: Abdelkader, Ahmed, et al.
Publicado: (2022)

In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia
por: Mahmoud, Amal, et al.
Publicado: (2021)

503. In vitro Evaluation of Sitagliptin-HIV-1 Trans-activator Transcription Peptide Nano-formula for Antiviral Activity Against SARS-CoV-2: Drug Repurposing Approach
por: Eljaaly, Khalid, et al.
Publicado: (2021)

Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2
por: Kandeil, Ahmed, et al.
Publicado: (2020)

Computational Identification of Tissue-Specific Splicing Regulatory Elements in Human Genes from RNA-Seq Data
por: Badr, Eman, et al.
Publicado: (2016)

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies
por: Mahmoud, Dina B., et al.
Publicado: (2021)

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science
por: Mostafa, Ahmed, et al.
Publicado: (2020)

Scrutinizing the Feasibility of Nonionic Surfactants to Form Isotropic Bicelles of Curcumin: a Potential Antiviral Candidate Against COVID-19
por: Mahmoud, Dina B., et al.
Publicado: (2021)

A Recombinant Influenza A/H1N1 Carrying A Short Immunogenic Peptide of MERS-CoV as Bivalent Vaccine in BALB/c Mice
por: Shehata, Mahmoud M., et al.
Publicado: (2019)

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002
por: Hamza, Hazem, et al.
Publicado: (2021)

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization
por: Abo Elmaaty, Ayman, et al.
Publicado: (2021)

Co-regulatory Network of Oncosuppressor miRNAs and Transcription Factors for Pathology of Human Hepatic Cancer Stem Cells (HCSC)
por: Mohamed, Rania Hassan, et al.
Publicado: (2019)

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval
por: Ashour, Nada A, et al.
Publicado: (2022)

Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase
por: Abidi, Syed Hani, et al.
Publicado: (2021)

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease
por: Elagawany, Mohamed, et al.
Publicado: (2022)

Successful stories of drug repurposing for cancer therapy in hepatocellular carcinoma
por: Attia, Yasmeen M., et al.
Publicado: (2020)

Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study
por: Elsayed, Mahmoud M. A., et al.
Publicado: (2022)

Management strategy and outcomes of sacrococcygeal teratoma — an Egyptian multicenter experience
por: Elgendy, Ahmed, et al.
Publicado: (2023)

Immunogenicity and effectiveness of a bivalent influenza A/H1N2 vaccine strain against seasonal human influenza A viruses in mice
por: Kamel, Mina Nabil, et al.
Publicado: (2022)

MysiRNA-Designer: A Workflow for Efficient siRNA Design
por: Mysara, Mohamed, et al.
Publicado: (2011)

Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors
por: ElHefnawi, Mahmoud, et al.
Publicado: (2012)

In silico identification of potential key regulatory factors in smoking-induced lung cancer
por: El-aarag, Salem A., et al.
Publicado: (2017)

Repurposing FDA-approved phytomedicines, natural products, antivirals and cell protectives against SARS-CoV-2 (COVID-19) RNA-dependent RNA polymerase
por: Kandeel, Mahmoud, et al.
Publicado: (2020)

Telaprevir Experience From Turkey
por: Komur, Suheyla, et al.
Publicado: (2015)

Cutaneous Eruption due to Telaprevir
por: Falcão, Eduardo Mastrangelo Marinho, et al.
Publicado: (2015)

Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein Antigens
por: Mabrouk, Moustafa T., et al.
Publicado: (2023)

Spiroindole-containing compounds bearing phosphonate group of potential M(pro)-SARS-CoV-2 inhibitory properties
por: Bekheit, Mohamed S., et al.
Publicado: (2023)

In Vitro Study on Effect of Zinc Oxide Nanoparticles on the Biological Activities of Croton tiglium L. Seeds Extracts
por: Aboulthana, Wael Mahmoud, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dm8jipogi21tu1qkbkcs3g0dcu