Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse

Mitochondrial dysfunction may activate innate immunity, e.g. upon abnormal handling of mitochondrial DNA in TFAM mutants or in altered mitophagy. Recent reports showed that also deletion of mitochondrial matrix peptidase ClpP in mice triggers transcriptional upregulation of inflammatory factors. Her...

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Detalles Bibliográficos
Autores principales: Maletzko, Antonia, Key, Jana, Wittig, Ilka, Gispert, Suzana, Koepf, Gabriele, Canet-Pons, Júlia, Torres-Odio, Sylvia, West, A. Phillip, Auburger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426249/
https://www.ncbi.nlm.nih.gov/pubmed/34345994
http://dx.doi.org/10.1007/s10048-021-00657-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426249/
https://www.ncbi.nlm.nih.gov/pubmed/34345994
http://dx.doi.org/10.1007/s10048-021-00657-2

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