High expression of CD38 and MHC class II on CD8(+) T cells during severe influenza disease reflects bystander activation and trogocytosis

OBJECTIVES: Although co‐expression of CD38 and HLA‐DR reflects T‐cell activation during viral infections, high and prolonged CD38(+)HLA‐DR(+) expression is associated with severe disease. To date, the mechanism underpinning expression of CD38(+)HLA‐DR(+) is poorly understood. METHODS: We used mouse...

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Detalles Bibliográficos
Autores principales: Jia, Xiaoxiao, Chua, Brendon Y, Loh, Liyen, Koutsakos, Marios, Kedzierski, Lukasz, Olshansky, Moshe, Heath, William R, Chang, So Young, Xu, Jianqing, Wang, Zhongfang, Kedzierska, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426257/
https://www.ncbi.nlm.nih.gov/pubmed/34522380
http://dx.doi.org/10.1002/cti2.1336

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