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Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog gene mutations

TAS-117 is a potent and selective allosteric pan-v-akt murine thymoma viral oncogene homolog (Akt) inhibitor. We conducted a single-arm single-center phase 2 study of TAS-117 in heavily treated patients with tumors refractory to systemic chemotherapy and harboring phosphatidylinositol 3-kinase (PI3K...

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Detalles Bibliográficos
Autores principales:	Lee, Jii Bum, Jung, Minkyu, Beom, Seung Hoon, Kim, Gun Min, Kim, Hye Ryun, Choi, Hye Jin, Sohn, Joo Hyuk, Ahn, Joong Bae, Rha, Sun Young, Chung, Hyun Cheol
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Phase II Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426297/ https://www.ncbi.nlm.nih.gov/pubmed/33723724 http://dx.doi.org/10.1007/s10637-021-01085-7

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