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Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma
As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the development of the central nervous system. The presence or absence of this special organelle may regulate the central nervous system tumor...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426355/ https://www.ncbi.nlm.nih.gov/pubmed/34513696 http://dx.doi.org/10.3389/fonc.2021.718995 |
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author | Li, Minghao Zhang, Jiaxun Zhou, Haonan Xiang, Rong |
author_facet | Li, Minghao Zhang, Jiaxun Zhou, Haonan Xiang, Rong |
author_sort | Li, Minghao |
collection | PubMed |
description | As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the development of the central nervous system. The presence or absence of this special organelle may regulate the central nervous system tumorigenesis (e.g., glioblastoma) and several degenerative diseases. Additionally, the development of primary cilia can be regulated by several pathways. Conversely, primary cilia are able to regulate a few signaling transduction pathways. Therefore, development of the central nervous system tumors in conjunction with abnormal cilia can be regulated by up- or downregulation of the pathways related to cilia and ciliogenesis. Here, we review some pathways related to ciliogenesis and tumorigenesis, aiming to provide a potential target for developing new therapies at genetic and molecular levels. |
format | Online Article Text |
id | pubmed-8426355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84263552021-09-10 Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma Li, Minghao Zhang, Jiaxun Zhou, Haonan Xiang, Rong Front Oncol Oncology As microtubule-based structures, primary cilia are typically present on the cells during the G0 or G1-S/G2 phase of the cell cycle and are closely related to the development of the central nervous system. The presence or absence of this special organelle may regulate the central nervous system tumorigenesis (e.g., glioblastoma) and several degenerative diseases. Additionally, the development of primary cilia can be regulated by several pathways. Conversely, primary cilia are able to regulate a few signaling transduction pathways. Therefore, development of the central nervous system tumors in conjunction with abnormal cilia can be regulated by up- or downregulation of the pathways related to cilia and ciliogenesis. Here, we review some pathways related to ciliogenesis and tumorigenesis, aiming to provide a potential target for developing new therapies at genetic and molecular levels. Frontiers Media S.A. 2021-08-26 /pmc/articles/PMC8426355/ /pubmed/34513696 http://dx.doi.org/10.3389/fonc.2021.718995 Text en Copyright © 2021 Li, Zhang, Zhou and Xiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Minghao Zhang, Jiaxun Zhou, Haonan Xiang, Rong Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title | Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title_full | Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title_fullStr | Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title_full_unstemmed | Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title_short | Primary Cilia–Related Pathways Moderate the Development and Therapy Resistance of Glioblastoma |
title_sort | primary cilia–related pathways moderate the development and therapy resistance of glioblastoma |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426355/ https://www.ncbi.nlm.nih.gov/pubmed/34513696 http://dx.doi.org/10.3389/fonc.2021.718995 |
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