Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist. The SAE of healthy nonsmokers and healthy cigarette smokers were evaluated by single-cell RNA sequencing, and uns...

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Detalles Bibliográficos
Autores principales: Rostami, Mahboubeh R., LeBlanc, Michelle G., Strulovici-Barel, Yael, Zuo, Wulin, Mezey, Jason G., O’Beirne, Sarah L., Kaner, Robert J., Leopold, Philip L., Crystal, Ronald G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426481/
https://www.ncbi.nlm.nih.gov/pubmed/34497273
http://dx.doi.org/10.1038/s41525-021-00237-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426481/
https://www.ncbi.nlm.nih.gov/pubmed/34497273
http://dx.doi.org/10.1038/s41525-021-00237-1

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