Cargando…

CISD3 inhibition drives cystine-deprivation induced ferroptosis

Ferroptosis, a new form of programmed cell death, not only promotes the pathological process of various human diseases, but also regulates cancer progression. Current perspectives on the underlying mechanisms remain largely unknown. Herein, we report a member of the NEET protein family, CISD3, exert...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yanchun, Wang, Xin, Huang, Zhihui, Zhou, Yi, Xia, Jun, Hu, Wanye, Wang, Xu, Du, Jing, Tong, Xiangmin, Wang, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426496/ https://www.ncbi.nlm.nih.gov/pubmed/34497268 http://dx.doi.org/10.1038/s41419-021-04128-2

Ejemplares similares

Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway
por: Li, Yanchun, et al.
Publicado: (2022)

Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction
por: Shao, Fangchun, et al.
Publicado: (2021)

Correction: Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway
por: Li, Yanchun, et al.
Publicado: (2023)

Identification of Frataxin as a regulator of ferroptosis
por: Du, Jing, et al.
Publicado: (2020)

Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis
por: Yang, Jing, et al.
Publicado: (2022)

Corrigendum to “Identification of Frataxin as a regulator of ferroptosis” [Redox Biol. 32 (2020) 101483]
por: Du, Jing, et al.
Publicado: (2023)

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
por: Shin, Daiha, et al.
Publicado: (2020)

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism
por: Du, Jing, et al.
Publicado: (2021)

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
por: Ren, Xueying, et al.
Publicado: (2021)

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
por: Hayano, M, et al.
Publicado: (2016)

Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma
por: Shen, Zhao-Qing, et al.
Publicado: (2018)

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells
por: Yang, Chen, et al.
Publicado: (2021)

Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation–induced ferroptosis
por: Hayashima, Kazuki, et al.
Publicado: (2022)

FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis
por: Hu, Wanye, et al.
Publicado: (2021)

CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
por: Li, Bowen, et al.
Publicado: (2021)

COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism
por: Feng, Yetong, et al.
Publicado: (2022)

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
por: Dixon, Scott J, et al.
Publicado: (2014)

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
por: Shi, Zhennan, et al.
Publicado: (2021)

Ferroptosis-associated gene CISD2 suppresses colon cancer development by regulating tumor immune microenvironment
por: Xu, Yuanyuan, et al.
Publicado: (2023)

NRF2 regulates the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via FOCAD-FAK signaling pathway
por: Liu, Pengfei, et al.
Publicado: (2020)

Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model
por: Lin, Chai-Ching, et al.
Publicado: (2019)

Author Correction: Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
por: Shi, Zhennan, et al.
Publicado: (2023)

Enhancing CISD2 expression to retard liver aging
por: Huang, Yi-Long, et al.
Publicado: (2022)

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition
por: Muir, Alexander, et al.
Publicado: (2017)

Autophagy-related prognostic signature characterizes tumor microenvironment and predicts response to ferroptosis in gastric cancer
por: Li, Haoran, et al.
Publicado: (2022)

The mitochondrial localized CISD-3.1/CISD-3.2 proteins are required to maintain normal germline structure and function in Caenorhabditis elegans
por: King, Skylar D., et al.
Publicado: (2021)

Upregulation of Cisd2 attenuates Alzheimer's‐related neuronal loss in mice
por: Chen, Yi‐Fan, et al.
Publicado: (2020)

Rejuvenation: Turning Back Time by Enhancing CISD2
por: Yeh, Chi-Hsiao, et al.
Publicado: (2022)

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis
por: Yu, Xinlei, et al.
Publicado: (2016)

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1
por: Cho, Il-Je, et al.
Publicado: (2021)

SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes
por: Tong, Qing, et al.
Publicado: (2023)

Rejuvenating the Aging Heart by Enhancing the Expression of the Cisd2 Prolongevity Gene
por: Yeh, Chi-Hsiao, et al.
Publicado: (2021)

Glutamine deprivation induces ferroptosis in pancreatic cancer cells: Glutamine deprivation induces pancreatic cancer ferroptosis
por: Xiao, Zhiwen, et al.
Publicado: (2023)

Exercise and the Cisd2 Prolongevity Gene: Two Promising Strategies to Delay the Aging of Skeletal Muscle
por: Teng, Yuan-Chi, et al.
Publicado: (2020)

Intracellular targeting of Cisd2/Miner1 to the endoplasmic reticulum
por: Bian, Claudie, et al.
Publicado: (2021)

Cisd2 plays an essential role in corneal epithelial regeneration
por: Sun, Chi-Chin, et al.
Publicado: (2021)

Overexpression of CISD1 Predicts Worse Survival in Hepatocarcinoma Patients
por: Lu, Tailiang, et al.
Publicado: (2022)

Identification of CISD1 as a Prognostic Biomarker for Breast Cancer
por: Liu, Xiao, et al.
Publicado: (2022)

MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex
por: Zhang, Zi-Bin, et al.
Publicado: (2021)

Cisd2 is essential to delaying cardiac aging and to maintaining heart functions
por: Yeh, Chi-Hsiao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jnl4e8rlp6nbe6ssgq8ua95n61