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A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis

Colovesical fistula (CVF) is an abnormal connection between the colon and the urinary bladder. Faecaluria, reported in 40–70% of cases, is virtually pathognomonic for CVF. During the 5th day of recovery in an 84 years old subject, the passage of cloudy, malodorous urine with visible debris was obser...

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Autores principales: Rapi, S., Bonari, A., Dugheri, S., Cappelli, G., Trevisani, L., Milletti, E., Mucci, N., Arcangeli, G., Morettini, A., Fanelli, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426557/
https://www.ncbi.nlm.nih.gov/pubmed/34522752
http://dx.doi.org/10.1016/j.plabm.2021.e00255
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author Rapi, S.
Bonari, A.
Dugheri, S.
Cappelli, G.
Trevisani, L.
Milletti, E.
Mucci, N.
Arcangeli, G.
Morettini, A.
Fanelli, A.
author_facet Rapi, S.
Bonari, A.
Dugheri, S.
Cappelli, G.
Trevisani, L.
Milletti, E.
Mucci, N.
Arcangeli, G.
Morettini, A.
Fanelli, A.
author_sort Rapi, S.
collection PubMed
description Colovesical fistula (CVF) is an abnormal connection between the colon and the urinary bladder. Faecaluria, reported in 40–70% of cases, is virtually pathognomonic for CVF. During the 5th day of recovery in an 84 years old subject, the passage of cloudy, malodorous urine with visible debris was observed. According to the pathognomonic character of faecaluria, the sample was signed to the laboratory for biochemical and microbiological investigation, able to define the type and origin of materials. Following clinical requirements, both biochemical pathways and instrumental procedures able to confirm or exclude the presence of faecal components in urine were considered. No biochemical compound or component addressing faecal compounds in urine results available between laboratory tests. The brown powder component of the pellet was identified as Keratin, with 90% overlapping with the reference spectrum of the compound. FT-IR analysis on urine pellet can be proposed as a simple, non-invasive, and fast method to improve the diagnostic course of CVF.
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spelling pubmed-84265572021-09-13 A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis Rapi, S. Bonari, A. Dugheri, S. Cappelli, G. Trevisani, L. Milletti, E. Mucci, N. Arcangeli, G. Morettini, A. Fanelli, A. Pract Lab Med Article Colovesical fistula (CVF) is an abnormal connection between the colon and the urinary bladder. Faecaluria, reported in 40–70% of cases, is virtually pathognomonic for CVF. During the 5th day of recovery in an 84 years old subject, the passage of cloudy, malodorous urine with visible debris was observed. According to the pathognomonic character of faecaluria, the sample was signed to the laboratory for biochemical and microbiological investigation, able to define the type and origin of materials. Following clinical requirements, both biochemical pathways and instrumental procedures able to confirm or exclude the presence of faecal components in urine were considered. No biochemical compound or component addressing faecal compounds in urine results available between laboratory tests. The brown powder component of the pellet was identified as Keratin, with 90% overlapping with the reference spectrum of the compound. FT-IR analysis on urine pellet can be proposed as a simple, non-invasive, and fast method to improve the diagnostic course of CVF. Elsevier 2021-09-01 /pmc/articles/PMC8426557/ /pubmed/34522752 http://dx.doi.org/10.1016/j.plabm.2021.e00255 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Rapi, S.
Bonari, A.
Dugheri, S.
Cappelli, G.
Trevisani, L.
Milletti, E.
Mucci, N.
Arcangeli, G.
Morettini, A.
Fanelli, A.
A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title_full A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title_fullStr A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title_full_unstemmed A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title_short A case report: Use of FT-IR analysis to improve Colovesical fistula diagnosis
title_sort case report: use of ft-ir analysis to improve colovesical fistula diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426557/
https://www.ncbi.nlm.nih.gov/pubmed/34522752
http://dx.doi.org/10.1016/j.plabm.2021.e00255
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