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Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmissio...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426594/ https://www.ncbi.nlm.nih.gov/pubmed/34518763 http://dx.doi.org/10.1007/s10924-021-02272-6 |
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author | Umar, Yunusa Al-Batty, Sirhan Rahman, Habibur Ashwaq, Omar Sarief, Abdulla Sadique, Zakariya Sreekumar, P. A. Haque, S. K. Manirul |
author_facet | Umar, Yunusa Al-Batty, Sirhan Rahman, Habibur Ashwaq, Omar Sarief, Abdulla Sadique, Zakariya Sreekumar, P. A. Haque, S. K. Manirul |
author_sort | Umar, Yunusa |
collection | PubMed |
description | Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmission as studied by some factors such as basic reproduction number, case fatality rate, and incubation period in the epidemiology of viral diseases. This review briefly discusses coronaviruses' life cycle of SARS-CoV-2 in a human host cell and preventive strategies at some selected source of infection. The antiviral activities of synthetic and natural polymers such as chitosan, hydrophobically modified chitosan, galactosylated chitosan, amine-based dendrimers, cyclodextrin, carrageenans, polyethyleneimine, nanoparticles are highlighted in this article. Mechanism of virus inhibition, detection and diagnosis are also presented. It also suggests that polymeric materials and nanoparticles can be effective as potential inhibitors and immunization against coronaviruses which would further develop new technologies in the field of polymer and nanoscience. |
format | Online Article Text |
id | pubmed-8426594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-84265942021-09-09 Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 Umar, Yunusa Al-Batty, Sirhan Rahman, Habibur Ashwaq, Omar Sarief, Abdulla Sadique, Zakariya Sreekumar, P. A. Haque, S. K. Manirul J Polym Environ Review Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmission as studied by some factors such as basic reproduction number, case fatality rate, and incubation period in the epidemiology of viral diseases. This review briefly discusses coronaviruses' life cycle of SARS-CoV-2 in a human host cell and preventive strategies at some selected source of infection. The antiviral activities of synthetic and natural polymers such as chitosan, hydrophobically modified chitosan, galactosylated chitosan, amine-based dendrimers, cyclodextrin, carrageenans, polyethyleneimine, nanoparticles are highlighted in this article. Mechanism of virus inhibition, detection and diagnosis are also presented. It also suggests that polymeric materials and nanoparticles can be effective as potential inhibitors and immunization against coronaviruses which would further develop new technologies in the field of polymer and nanoscience. Springer US 2021-09-09 2022 /pmc/articles/PMC8426594/ /pubmed/34518763 http://dx.doi.org/10.1007/s10924-021-02272-6 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Umar, Yunusa Al-Batty, Sirhan Rahman, Habibur Ashwaq, Omar Sarief, Abdulla Sadique, Zakariya Sreekumar, P. A. Haque, S. K. Manirul Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title | Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title_full | Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title_fullStr | Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title_full_unstemmed | Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title_short | Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 |
title_sort | polymeric materials as potential inhibitors against sars-cov-2 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426594/ https://www.ncbi.nlm.nih.gov/pubmed/34518763 http://dx.doi.org/10.1007/s10924-021-02272-6 |
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