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Polymeric Materials as Potential Inhibitors Against SARS-CoV-2

Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmissio...

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Autores principales: Umar, Yunusa, Al-Batty, Sirhan, Rahman, Habibur, Ashwaq, Omar, Sarief, Abdulla, Sadique, Zakariya, Sreekumar, P. A., Haque, S. K. Manirul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426594/
https://www.ncbi.nlm.nih.gov/pubmed/34518763
http://dx.doi.org/10.1007/s10924-021-02272-6
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author Umar, Yunusa
Al-Batty, Sirhan
Rahman, Habibur
Ashwaq, Omar
Sarief, Abdulla
Sadique, Zakariya
Sreekumar, P. A.
Haque, S. K. Manirul
author_facet Umar, Yunusa
Al-Batty, Sirhan
Rahman, Habibur
Ashwaq, Omar
Sarief, Abdulla
Sadique, Zakariya
Sreekumar, P. A.
Haque, S. K. Manirul
author_sort Umar, Yunusa
collection PubMed
description Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmission as studied by some factors such as basic reproduction number, case fatality rate, and incubation period in the epidemiology of viral diseases. This review briefly discusses coronaviruses' life cycle of SARS-CoV-2 in a human host cell and preventive strategies at some selected source of infection. The antiviral activities of synthetic and natural polymers such as chitosan, hydrophobically modified chitosan, galactosylated chitosan, amine-based dendrimers, cyclodextrin, carrageenans, polyethyleneimine, nanoparticles are highlighted in this article. Mechanism of virus inhibition, detection and diagnosis are also presented. It also suggests that polymeric materials and nanoparticles can be effective as potential inhibitors and immunization against coronaviruses which would further develop new technologies in the field of polymer and nanoscience.
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spelling pubmed-84265942021-09-09 Polymeric Materials as Potential Inhibitors Against SARS-CoV-2 Umar, Yunusa Al-Batty, Sirhan Rahman, Habibur Ashwaq, Omar Sarief, Abdulla Sadique, Zakariya Sreekumar, P. A. Haque, S. K. Manirul J Polym Environ Review Recently discovered SARS-CoV-2 caused a pandemic that triggered researchers worldwide to focus their research on all aspects of this new peril to humanity. However, in the absence of specific therapeutic intervention, some preventive strategies and supportive treatment minimize the viral transmission as studied by some factors such as basic reproduction number, case fatality rate, and incubation period in the epidemiology of viral diseases. This review briefly discusses coronaviruses' life cycle of SARS-CoV-2 in a human host cell and preventive strategies at some selected source of infection. The antiviral activities of synthetic and natural polymers such as chitosan, hydrophobically modified chitosan, galactosylated chitosan, amine-based dendrimers, cyclodextrin, carrageenans, polyethyleneimine, nanoparticles are highlighted in this article. Mechanism of virus inhibition, detection and diagnosis are also presented. It also suggests that polymeric materials and nanoparticles can be effective as potential inhibitors and immunization against coronaviruses which would further develop new technologies in the field of polymer and nanoscience. Springer US 2021-09-09 2022 /pmc/articles/PMC8426594/ /pubmed/34518763 http://dx.doi.org/10.1007/s10924-021-02272-6 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Umar, Yunusa
Al-Batty, Sirhan
Rahman, Habibur
Ashwaq, Omar
Sarief, Abdulla
Sadique, Zakariya
Sreekumar, P. A.
Haque, S. K. Manirul
Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title_full Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title_fullStr Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title_full_unstemmed Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title_short Polymeric Materials as Potential Inhibitors Against SARS-CoV-2
title_sort polymeric materials as potential inhibitors against sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426594/
https://www.ncbi.nlm.nih.gov/pubmed/34518763
http://dx.doi.org/10.1007/s10924-021-02272-6
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