Cargando…

Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets

The links between early life stress (ELS) and the emergence of psychopathology such as increased anxiety and depression are now well established, although the specific neurobiological and developmental mechanisms that translate ELS into poor health outcomes are still unclear. The consequences of ELS...

Descripción completa

Detalles Bibliográficos
Autores principales: Guadagno, Angela, Belliveau, Claudia, Mechawar, Naguib, Walker, Claire-Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426628/
https://www.ncbi.nlm.nih.gov/pubmed/34512291
http://dx.doi.org/10.3389/fnhum.2021.669120
_version_ 1783750083780542464
author Guadagno, Angela
Belliveau, Claudia
Mechawar, Naguib
Walker, Claire-Dominique
author_facet Guadagno, Angela
Belliveau, Claudia
Mechawar, Naguib
Walker, Claire-Dominique
author_sort Guadagno, Angela
collection PubMed
description The links between early life stress (ELS) and the emergence of psychopathology such as increased anxiety and depression are now well established, although the specific neurobiological and developmental mechanisms that translate ELS into poor health outcomes are still unclear. The consequences of ELS are complex because they depend on the form and severity of early stress, duration, and age of exposure as well as co-occurrence with other forms of physical or psychological trauma. The long term effects of ELS on the corticolimbic circuit underlying emotional and social behavior are particularly salient because ELS occurs during critical developmental periods in the establishment of this circuit, its local balance of inhibition:excitation and its connections with other neuronal pathways. Using examples drawn from the human and rodent literature, we review some of the consequences of ELS on the development of the corticolimbic circuit and how it might impact fear regulation in a sex- and hemispheric-dependent manner in both humans and rodents. We explore the effects of ELS on local inhibitory neurons and the formation of perineuronal nets (PNNs) that terminate critical periods of plasticity and promote the formation of stable local networks. Overall, the bulk of ELS studies report transient and/or long lasting alterations in both glutamatergic circuits and local inhibitory interneurons (INs) and their associated PNNs. Since the activity of INs plays a key role in the maturation of cortical regions and the formation of local field potentials, alterations in these INs triggered by ELS might critically participate in the development of psychiatric disorders in adulthood, including impaired fear extinction and anxiety behavior.
format Online
Article
Text
id pubmed-8426628
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84266282021-09-10 Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets Guadagno, Angela Belliveau, Claudia Mechawar, Naguib Walker, Claire-Dominique Front Hum Neurosci Neuroscience The links between early life stress (ELS) and the emergence of psychopathology such as increased anxiety and depression are now well established, although the specific neurobiological and developmental mechanisms that translate ELS into poor health outcomes are still unclear. The consequences of ELS are complex because they depend on the form and severity of early stress, duration, and age of exposure as well as co-occurrence with other forms of physical or psychological trauma. The long term effects of ELS on the corticolimbic circuit underlying emotional and social behavior are particularly salient because ELS occurs during critical developmental periods in the establishment of this circuit, its local balance of inhibition:excitation and its connections with other neuronal pathways. Using examples drawn from the human and rodent literature, we review some of the consequences of ELS on the development of the corticolimbic circuit and how it might impact fear regulation in a sex- and hemispheric-dependent manner in both humans and rodents. We explore the effects of ELS on local inhibitory neurons and the formation of perineuronal nets (PNNs) that terminate critical periods of plasticity and promote the formation of stable local networks. Overall, the bulk of ELS studies report transient and/or long lasting alterations in both glutamatergic circuits and local inhibitory interneurons (INs) and their associated PNNs. Since the activity of INs plays a key role in the maturation of cortical regions and the formation of local field potentials, alterations in these INs triggered by ELS might critically participate in the development of psychiatric disorders in adulthood, including impaired fear extinction and anxiety behavior. Frontiers Media S.A. 2021-08-26 /pmc/articles/PMC8426628/ /pubmed/34512291 http://dx.doi.org/10.3389/fnhum.2021.669120 Text en Copyright © 2021 Guadagno, Belliveau, Mechawar and Walker. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Guadagno, Angela
Belliveau, Claudia
Mechawar, Naguib
Walker, Claire-Dominique
Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title_full Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title_fullStr Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title_full_unstemmed Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title_short Effects of Early Life Stress on the Developing Basolateral Amygdala-Prefrontal Cortex Circuit: The Emerging Role of Local Inhibition and Perineuronal Nets
title_sort effects of early life stress on the developing basolateral amygdala-prefrontal cortex circuit: the emerging role of local inhibition and perineuronal nets
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426628/
https://www.ncbi.nlm.nih.gov/pubmed/34512291
http://dx.doi.org/10.3389/fnhum.2021.669120
work_keys_str_mv AT guadagnoangela effectsofearlylifestressonthedevelopingbasolateralamygdalaprefrontalcortexcircuittheemergingroleoflocalinhibitionandperineuronalnets
AT belliveauclaudia effectsofearlylifestressonthedevelopingbasolateralamygdalaprefrontalcortexcircuittheemergingroleoflocalinhibitionandperineuronalnets
AT mechawarnaguib effectsofearlylifestressonthedevelopingbasolateralamygdalaprefrontalcortexcircuittheemergingroleoflocalinhibitionandperineuronalnets
AT walkerclairedominique effectsofearlylifestressonthedevelopingbasolateralamygdalaprefrontalcortexcircuittheemergingroleoflocalinhibitionandperineuronalnets