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Tricin Biosynthesis and Bioengineering

Tricin (3',5'-dimethoxyflavone) is a specialized metabolite which not only confers stress tolerance and involves in defense responses in plants but also represents a promising nutraceutical. Tricin-type metabolites are widely present as soluble tricin O-glycosides and tricin-oligolignols i...

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Autores principales: Lam, Pui Ying, Lui, Andy C. W., Wang, Lanxiang, Liu, Hongjia, Umezawa, Toshiaki, Tobimatsu, Yuki, Lo, Clive
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426635/
https://www.ncbi.nlm.nih.gov/pubmed/34512707
http://dx.doi.org/10.3389/fpls.2021.733198
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author Lam, Pui Ying
Lui, Andy C. W.
Wang, Lanxiang
Liu, Hongjia
Umezawa, Toshiaki
Tobimatsu, Yuki
Lo, Clive
author_facet Lam, Pui Ying
Lui, Andy C. W.
Wang, Lanxiang
Liu, Hongjia
Umezawa, Toshiaki
Tobimatsu, Yuki
Lo, Clive
author_sort Lam, Pui Ying
collection PubMed
description Tricin (3',5'-dimethoxyflavone) is a specialized metabolite which not only confers stress tolerance and involves in defense responses in plants but also represents a promising nutraceutical. Tricin-type metabolites are widely present as soluble tricin O-glycosides and tricin-oligolignols in all grass species examined, but only show patchy occurrences in unrelated lineages in dicots. More strikingly, tricin is a lignin monomer in grasses and several other angiosperm species, representing one of the “non-monolignol” lignin monomers identified in nature. The unique biological functions of tricin especially as a lignin monomer have driven the identification and characterization of tricin biosynthetic enzymes in the past decade. This review summarizes the current understanding of tricin biosynthetic pathway in grasses and tricin-accumulating dicots. The characterized and potential enzymes involved in tricin biosynthesis are highlighted along with discussion on the debatable and uncharacterized steps. Finally, current developments of bioengineering on manipulating tricin biosynthesis toward the generation of functional food as well as modifications of lignin for improving biorefinery applications are summarized.
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spelling pubmed-84266352021-09-10 Tricin Biosynthesis and Bioengineering Lam, Pui Ying Lui, Andy C. W. Wang, Lanxiang Liu, Hongjia Umezawa, Toshiaki Tobimatsu, Yuki Lo, Clive Front Plant Sci Plant Science Tricin (3',5'-dimethoxyflavone) is a specialized metabolite which not only confers stress tolerance and involves in defense responses in plants but also represents a promising nutraceutical. Tricin-type metabolites are widely present as soluble tricin O-glycosides and tricin-oligolignols in all grass species examined, but only show patchy occurrences in unrelated lineages in dicots. More strikingly, tricin is a lignin monomer in grasses and several other angiosperm species, representing one of the “non-monolignol” lignin monomers identified in nature. The unique biological functions of tricin especially as a lignin monomer have driven the identification and characterization of tricin biosynthetic enzymes in the past decade. This review summarizes the current understanding of tricin biosynthetic pathway in grasses and tricin-accumulating dicots. The characterized and potential enzymes involved in tricin biosynthesis are highlighted along with discussion on the debatable and uncharacterized steps. Finally, current developments of bioengineering on manipulating tricin biosynthesis toward the generation of functional food as well as modifications of lignin for improving biorefinery applications are summarized. Frontiers Media S.A. 2021-08-26 /pmc/articles/PMC8426635/ /pubmed/34512707 http://dx.doi.org/10.3389/fpls.2021.733198 Text en Copyright © 2021 Lam, Lui, Wang, Liu, Umezawa, Tobimatsu and Lo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Lam, Pui Ying
Lui, Andy C. W.
Wang, Lanxiang
Liu, Hongjia
Umezawa, Toshiaki
Tobimatsu, Yuki
Lo, Clive
Tricin Biosynthesis and Bioengineering
title Tricin Biosynthesis and Bioengineering
title_full Tricin Biosynthesis and Bioengineering
title_fullStr Tricin Biosynthesis and Bioengineering
title_full_unstemmed Tricin Biosynthesis and Bioengineering
title_short Tricin Biosynthesis and Bioengineering
title_sort tricin biosynthesis and bioengineering
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426635/
https://www.ncbi.nlm.nih.gov/pubmed/34512707
http://dx.doi.org/10.3389/fpls.2021.733198
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