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Anticonvulsant use and fracture: a case-control study

OBJECTIVES: We aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women. METHODS: Data from 1,458 participants (51.8% women) with a radiologically confirmed incident fracture (cases) were compared to 1,796 participants (46.5% women) without...

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Autores principales: Chandrasekaran, Vinoomika, Stuart, Amanda L., Pasco, Julie A., Brennan-Olsen, Sharon L., Berk, Michael, Hodge, Jason M., Samarasinghe, Rasika M., Williams, Lana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426646/
https://www.ncbi.nlm.nih.gov/pubmed/34465682
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author Chandrasekaran, Vinoomika
Stuart, Amanda L.
Pasco, Julie A.
Brennan-Olsen, Sharon L.
Berk, Michael
Hodge, Jason M.
Samarasinghe, Rasika M.
Williams, Lana J.
author_facet Chandrasekaran, Vinoomika
Stuart, Amanda L.
Pasco, Julie A.
Brennan-Olsen, Sharon L.
Berk, Michael
Hodge, Jason M.
Samarasinghe, Rasika M.
Williams, Lana J.
author_sort Chandrasekaran, Vinoomika
collection PubMed
description OBJECTIVES: We aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women. METHODS: Data from 1,458 participants (51.8% women) with a radiologically confirmed incident fracture (cases) were compared to 1,796 participants (46.5% women) without fracture (controls). Lifestyle factors, medication use and medical history were self-reported. Associations between anticonvulsant use and fracture were explored using binary logistic regression following adjustment for confounders. RESULTS: In men, fracture cases and controls differed in age, smoking history, education, alcohol use, and gonadal hormone supplementation. In women, fracture cases and controls differed by previous fracture history, alcohol use, physical activity levels and use of anti-fracture agents. After adjustment for age, pooled anticonvulsant use was associated with a 3.4-fold higher risk of fracture in men and a 1.8-fold higher risk in women. Following further adjustments for confounders these patterns persisted; a 2.8-fold higher fracture risk in men and a 1.8-fold higher fracture risk in women. CONCLUSIONS: Anticonvulsant use was associated with increased fracture risk, independent of demographic, lifestyle, medical and medication related factors. While further studies exploring potential underlying mechanisms are warranted, regular monitoring of bone health in anticonvulsant users with risk factors may be useful.
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spelling pubmed-84266462021-09-13 Anticonvulsant use and fracture: a case-control study Chandrasekaran, Vinoomika Stuart, Amanda L. Pasco, Julie A. Brennan-Olsen, Sharon L. Berk, Michael Hodge, Jason M. Samarasinghe, Rasika M. Williams, Lana J. J Musculoskelet Neuronal Interact Original Article OBJECTIVES: We aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women. METHODS: Data from 1,458 participants (51.8% women) with a radiologically confirmed incident fracture (cases) were compared to 1,796 participants (46.5% women) without fracture (controls). Lifestyle factors, medication use and medical history were self-reported. Associations between anticonvulsant use and fracture were explored using binary logistic regression following adjustment for confounders. RESULTS: In men, fracture cases and controls differed in age, smoking history, education, alcohol use, and gonadal hormone supplementation. In women, fracture cases and controls differed by previous fracture history, alcohol use, physical activity levels and use of anti-fracture agents. After adjustment for age, pooled anticonvulsant use was associated with a 3.4-fold higher risk of fracture in men and a 1.8-fold higher risk in women. Following further adjustments for confounders these patterns persisted; a 2.8-fold higher fracture risk in men and a 1.8-fold higher fracture risk in women. CONCLUSIONS: Anticonvulsant use was associated with increased fracture risk, independent of demographic, lifestyle, medical and medication related factors. While further studies exploring potential underlying mechanisms are warranted, regular monitoring of bone health in anticonvulsant users with risk factors may be useful. International Society of Musculoskeletal and Neuronal Interactions 2021 /pmc/articles/PMC8426646/ /pubmed/34465682 Text en Copyright: © Journal of Musculoskeletal and Neuronal Interactions https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chandrasekaran, Vinoomika
Stuart, Amanda L.
Pasco, Julie A.
Brennan-Olsen, Sharon L.
Berk, Michael
Hodge, Jason M.
Samarasinghe, Rasika M.
Williams, Lana J.
Anticonvulsant use and fracture: a case-control study
title Anticonvulsant use and fracture: a case-control study
title_full Anticonvulsant use and fracture: a case-control study
title_fullStr Anticonvulsant use and fracture: a case-control study
title_full_unstemmed Anticonvulsant use and fracture: a case-control study
title_short Anticonvulsant use and fracture: a case-control study
title_sort anticonvulsant use and fracture: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426646/
https://www.ncbi.nlm.nih.gov/pubmed/34465682
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