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Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice

The COVID‐19 pandemic, caused by the SARS‐CoV‐2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin‐like Dps from hyperthermophilic Sulfolobus islandicus, covalently coupled with SARS‐CoV‐2 antigens via the SpyCatcher system, forms stable multivalent dodecameric vacc...

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Detalles Bibliográficos
Autores principales:	Salzer, Ralf, Clark, Jordan J., Vaysburd, Marina, Chang, Veronica T., Albecka, Anna, Kiss, Leo, Sharma, Parul, Gonzalez Llamazares, Andres, Kipar, Anja, Hiscox, Julian A., Owen, Andrew, Aricescu, A. Radu, Stewart, James P., James, Leo C., Löwe, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Editor's Choice
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426897/ https://www.ncbi.nlm.nih.gov/pubmed/34331769 http://dx.doi.org/10.1002/1873-3468.14171

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