Cargando…

Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory

Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD’s popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatmen...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaplan, J. S., Wagner, J. K., Reid, K., McGuinness, F., Arvila, S., Brooks, M., Stevenson, H., Jones, J., Risch, B., McGillis, T., Budinich, R., Gambell, E., Predovich, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426900/
https://www.ncbi.nlm.nih.gov/pubmed/34512286
http://dx.doi.org/10.3389/fnbeh.2021.711639
_version_ 1783750111626526720
author Kaplan, J. S.
Wagner, J. K.
Reid, K.
McGuinness, F.
Arvila, S.
Brooks, M.
Stevenson, H.
Jones, J.
Risch, B.
McGillis, T.
Budinich, R.
Gambell, E.
Predovich, B.
author_facet Kaplan, J. S.
Wagner, J. K.
Reid, K.
McGuinness, F.
Arvila, S.
Brooks, M.
Stevenson, H.
Jones, J.
Risch, B.
McGillis, T.
Budinich, R.
Gambell, E.
Predovich, B.
author_sort Kaplan, J. S.
collection PubMed
description Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD’s popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatment of numerous symptoms associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, and depression. The relative recency of its use in the adolescent population has precluded investigation of its impact on the developing brain and the potential consequences that may present in adulthood. Therefore, there’s an urgency to identify whether prolonged adolescent CBD exposure has substantive impacts on the developing brain that impact behavioral and cognitive processes in adulthood. Here, we tested the effect of twice-daily intraperitoneal administrations of CBD (20 mg/kg) in male and female C57BL/6J mice during the adolescent period of 25–45 days on weight gain, and assays for locomotor behavior, anxiety, and spatial memory. Prolonged adolescent CBD exposure had no detrimental effects on locomotor activity in the open field, anxiety behavior on the elevated plus maze, or spatial memory in the Barnes Maze compared to vehicle-treated mice. Interestingly, CBD-treated mice had a faster rate of learning in the Barnes Maze. However, CBD-treated females had reduced weight gain during the exposure period. We conclude that prolonged adolescent CBD exposure in mice does not have substantive negative impacts on a range of behaviors in adulthood, may improve the rate of learning under certain conditions, and impacts weight gain in a sex-specific manner.
format Online
Article
Text
id pubmed-8426900
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84269002021-09-10 Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory Kaplan, J. S. Wagner, J. K. Reid, K. McGuinness, F. Arvila, S. Brooks, M. Stevenson, H. Jones, J. Risch, B. McGillis, T. Budinich, R. Gambell, E. Predovich, B. Front Behav Neurosci Neuroscience Cannabidiol (CBD) is a non-intoxicating phytocannabinoid whose purported therapeutic benefits and impression of a high safety profile has promoted its increasing popularity. CBD’s popularity is also increasing among children and adolescents who are being administered CBD, off label, for the treatment of numerous symptoms associated with autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, and depression. The relative recency of its use in the adolescent population has precluded investigation of its impact on the developing brain and the potential consequences that may present in adulthood. Therefore, there’s an urgency to identify whether prolonged adolescent CBD exposure has substantive impacts on the developing brain that impact behavioral and cognitive processes in adulthood. Here, we tested the effect of twice-daily intraperitoneal administrations of CBD (20 mg/kg) in male and female C57BL/6J mice during the adolescent period of 25–45 days on weight gain, and assays for locomotor behavior, anxiety, and spatial memory. Prolonged adolescent CBD exposure had no detrimental effects on locomotor activity in the open field, anxiety behavior on the elevated plus maze, or spatial memory in the Barnes Maze compared to vehicle-treated mice. Interestingly, CBD-treated mice had a faster rate of learning in the Barnes Maze. However, CBD-treated females had reduced weight gain during the exposure period. We conclude that prolonged adolescent CBD exposure in mice does not have substantive negative impacts on a range of behaviors in adulthood, may improve the rate of learning under certain conditions, and impacts weight gain in a sex-specific manner. Frontiers Media S.A. 2021-08-26 /pmc/articles/PMC8426900/ /pubmed/34512286 http://dx.doi.org/10.3389/fnbeh.2021.711639 Text en Copyright © 2021 Kaplan, Wagner, Reid, McGuinness, Arvila, Brooks, Stevenson, Jones, Risch, McGillis, Budinich, Gambell and Predovich. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kaplan, J. S.
Wagner, J. K.
Reid, K.
McGuinness, F.
Arvila, S.
Brooks, M.
Stevenson, H.
Jones, J.
Risch, B.
McGillis, T.
Budinich, R.
Gambell, E.
Predovich, B.
Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title_full Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title_fullStr Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title_full_unstemmed Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title_short Cannabidiol Exposure During the Mouse Adolescent Period Is Without Harmful Behavioral Effects on Locomotor Activity, Anxiety, and Spatial Memory
title_sort cannabidiol exposure during the mouse adolescent period is without harmful behavioral effects on locomotor activity, anxiety, and spatial memory
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426900/
https://www.ncbi.nlm.nih.gov/pubmed/34512286
http://dx.doi.org/10.3389/fnbeh.2021.711639
work_keys_str_mv AT kaplanjs cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT wagnerjk cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT reidk cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT mcguinnessf cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT arvilas cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT brooksm cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT stevensonh cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT jonesj cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT rischb cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT mcgillist cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT budinichr cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT gambelle cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory
AT predovichb cannabidiolexposureduringthemouseadolescentperiodiswithoutharmfulbehavioraleffectsonlocomotoractivityanxietyandspatialmemory