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Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation
PURPOSE: Optic nerves are part of the craniospinal irradiation (CSI) target volume. Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs-at-risk such as the lens. The magnitude of eye movement and its influence on CSI target- and avoidance volumes are unclear. W...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427085/ https://www.ncbi.nlm.nih.gov/pubmed/34522796 http://dx.doi.org/10.1016/j.ctro.2021.08.009 |
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author | Hoeben, Bianca A.W. Seravalli, Enrica Wood, Amber M.L. Bosman, Mirjam Matysiak, Witold P. Maduro, John H. van Lier, Astrid L.H.M.W. Maspero, Matteo Bol, Gijsbert H. Janssens, Geert O. |
author_facet | Hoeben, Bianca A.W. Seravalli, Enrica Wood, Amber M.L. Bosman, Mirjam Matysiak, Witold P. Maduro, John H. van Lier, Astrid L.H.M.W. Maspero, Matteo Bol, Gijsbert H. Janssens, Geert O. |
author_sort | Hoeben, Bianca A.W. |
collection | PubMed |
description | PURPOSE: Optic nerves are part of the craniospinal irradiation (CSI) target volume. Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs-at-risk such as the lens. The magnitude of eye movement and its influence on CSI target- and avoidance volumes are unclear. We aimed to evaluate the movement-range of lenses and optic nerves and its influence on dose distribution of several planning techniques. METHODS: Ten volunteers underwent MRI scans in various gaze directions (neutral, left, right, cranial, caudal). Lenses, orbital optic nerves, optic discs and CSI target volumes were delineated. 36-Gy cranial irradiation plans were constructed on synthetic CT images in neutral gaze, with Volumetric Modulated Arc Therapy, pencil-beam scanning proton therapy, and 3D-conventional photons. Movement-amplitudes of lenses and optic discs were analyzed, and influence of gaze direction on lens and orbital optic nerve dose distribution. RESULTS: Mean eye structures’ shift from neutral position was greatest in caudal gaze; −5.8±1.2 mm (±SD) for lenses and 7.0±2.0 mm for optic discs. In 3D-conventional plans, caudal gaze decreased Mean Lens Dose (MLD). In VMAT and proton plans, eye movements mainly increased MLD and diminished D98 orbital optic nerve (D98(OON)) coverage; mean MLD increased up to 5.5 Gy [total ΔMLD range −8.1 to 10.0 Gy], and mean D98(OON) decreased up to 3.3 Gy [total ΔD98(OON) range −13.6 to 1.2 Gy]. VMAT plans optimized for optic disc Internal Target Volume and lens Planning organ-at-Risk Volume resulted in higher MLD over gaze directions. D98(OON) became ≥95% of prescribed dose over 95/100 evaluated gaze directions, while all-gaze bilateral D98(OON) significantly changed in 1 of 10 volunteers. CONCLUSION: With modern CSI techniques, eye movements result in higher lens doses and a mean detriment for orbital optic nerve dose coverage of <10% of prescribed dose. |
format | Online Article Text |
id | pubmed-8427085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84270852021-09-13 Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation Hoeben, Bianca A.W. Seravalli, Enrica Wood, Amber M.L. Bosman, Mirjam Matysiak, Witold P. Maduro, John H. van Lier, Astrid L.H.M.W. Maspero, Matteo Bol, Gijsbert H. Janssens, Geert O. Clin Transl Radiat Oncol Article PURPOSE: Optic nerves are part of the craniospinal irradiation (CSI) target volume. Modern radiotherapy techniques achieve highly conformal target doses while avoiding organs-at-risk such as the lens. The magnitude of eye movement and its influence on CSI target- and avoidance volumes are unclear. We aimed to evaluate the movement-range of lenses and optic nerves and its influence on dose distribution of several planning techniques. METHODS: Ten volunteers underwent MRI scans in various gaze directions (neutral, left, right, cranial, caudal). Lenses, orbital optic nerves, optic discs and CSI target volumes were delineated. 36-Gy cranial irradiation plans were constructed on synthetic CT images in neutral gaze, with Volumetric Modulated Arc Therapy, pencil-beam scanning proton therapy, and 3D-conventional photons. Movement-amplitudes of lenses and optic discs were analyzed, and influence of gaze direction on lens and orbital optic nerve dose distribution. RESULTS: Mean eye structures’ shift from neutral position was greatest in caudal gaze; −5.8±1.2 mm (±SD) for lenses and 7.0±2.0 mm for optic discs. In 3D-conventional plans, caudal gaze decreased Mean Lens Dose (MLD). In VMAT and proton plans, eye movements mainly increased MLD and diminished D98 orbital optic nerve (D98(OON)) coverage; mean MLD increased up to 5.5 Gy [total ΔMLD range −8.1 to 10.0 Gy], and mean D98(OON) decreased up to 3.3 Gy [total ΔD98(OON) range −13.6 to 1.2 Gy]. VMAT plans optimized for optic disc Internal Target Volume and lens Planning organ-at-Risk Volume resulted in higher MLD over gaze directions. D98(OON) became ≥95% of prescribed dose over 95/100 evaluated gaze directions, while all-gaze bilateral D98(OON) significantly changed in 1 of 10 volunteers. CONCLUSION: With modern CSI techniques, eye movements result in higher lens doses and a mean detriment for orbital optic nerve dose coverage of <10% of prescribed dose. Elsevier 2021-08-29 /pmc/articles/PMC8427085/ /pubmed/34522796 http://dx.doi.org/10.1016/j.ctro.2021.08.009 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hoeben, Bianca A.W. Seravalli, Enrica Wood, Amber M.L. Bosman, Mirjam Matysiak, Witold P. Maduro, John H. van Lier, Astrid L.H.M.W. Maspero, Matteo Bol, Gijsbert H. Janssens, Geert O. Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title | Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title_full | Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title_fullStr | Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title_full_unstemmed | Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title_short | Influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
title_sort | influence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427085/ https://www.ncbi.nlm.nih.gov/pubmed/34522796 http://dx.doi.org/10.1016/j.ctro.2021.08.009 |
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