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Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel a...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427090/ https://www.ncbi.nlm.nih.gov/pubmed/34541403 http://dx.doi.org/10.1016/j.bioactmat.2021.07.002 |
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author | Li, Meng Bai, Jiaxiang Tao, Huaqiang Hao, Li Yin, Weiling Ren, Xiaoxue Gao, Ang Li, Ning Wang, Miao Fang, Shiyuan Xu, Yaozeng Chen, Liang Yang, Huilin Wang, Huaiyu Pan, Guoqing Geng, Dechun |
author_facet | Li, Meng Bai, Jiaxiang Tao, Huaqiang Hao, Li Yin, Weiling Ren, Xiaoxue Gao, Ang Li, Ning Wang, Miao Fang, Shiyuan Xu, Yaozeng Chen, Liang Yang, Huilin Wang, Huaiyu Pan, Guoqing Geng, Dechun |
author_sort | Li, Meng |
collection | PubMed |
description | Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements. |
format | Online Article Text |
id | pubmed-8427090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-84270902021-09-17 Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy Li, Meng Bai, Jiaxiang Tao, Huaqiang Hao, Li Yin, Weiling Ren, Xiaoxue Gao, Ang Li, Ning Wang, Miao Fang, Shiyuan Xu, Yaozeng Chen, Liang Yang, Huilin Wang, Huaiyu Pan, Guoqing Geng, Dechun Bioact Mater Article Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements. KeAi Publishing 2021-07-10 /pmc/articles/PMC8427090/ /pubmed/34541403 http://dx.doi.org/10.1016/j.bioactmat.2021.07.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Li, Meng Bai, Jiaxiang Tao, Huaqiang Hao, Li Yin, Weiling Ren, Xiaoxue Gao, Ang Li, Ning Wang, Miao Fang, Shiyuan Xu, Yaozeng Chen, Liang Yang, Huilin Wang, Huaiyu Pan, Guoqing Geng, Dechun Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title_full | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title_fullStr | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title_full_unstemmed | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title_short | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
title_sort | rational integration of defense and repair synergy on peek osteoimplants via biomimetic peptide clicking strategy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427090/ https://www.ncbi.nlm.nih.gov/pubmed/34541403 http://dx.doi.org/10.1016/j.bioactmat.2021.07.002 |
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