Cargando…

Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy

Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel a...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Meng, Bai, Jiaxiang, Tao, Huaqiang, Hao, Li, Yin, Weiling, Ren, Xiaoxue, Gao, Ang, Li, Ning, Wang, Miao, Fang, Shiyuan, Xu, Yaozeng, Chen, Liang, Yang, Huilin, Wang, Huaiyu, Pan, Guoqing, Geng, Dechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427090/
https://www.ncbi.nlm.nih.gov/pubmed/34541403
http://dx.doi.org/10.1016/j.bioactmat.2021.07.002
_version_ 1783750126172372992
author Li, Meng
Bai, Jiaxiang
Tao, Huaqiang
Hao, Li
Yin, Weiling
Ren, Xiaoxue
Gao, Ang
Li, Ning
Wang, Miao
Fang, Shiyuan
Xu, Yaozeng
Chen, Liang
Yang, Huilin
Wang, Huaiyu
Pan, Guoqing
Geng, Dechun
author_facet Li, Meng
Bai, Jiaxiang
Tao, Huaqiang
Hao, Li
Yin, Weiling
Ren, Xiaoxue
Gao, Ang
Li, Ning
Wang, Miao
Fang, Shiyuan
Xu, Yaozeng
Chen, Liang
Yang, Huilin
Wang, Huaiyu
Pan, Guoqing
Geng, Dechun
author_sort Li, Meng
collection PubMed
description Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements.
format Online
Article
Text
id pubmed-8427090
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher KeAi Publishing
record_format MEDLINE/PubMed
spelling pubmed-84270902021-09-17 Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy Li, Meng Bai, Jiaxiang Tao, Huaqiang Hao, Li Yin, Weiling Ren, Xiaoxue Gao, Ang Li, Ning Wang, Miao Fang, Shiyuan Xu, Yaozeng Chen, Liang Yang, Huilin Wang, Huaiyu Pan, Guoqing Geng, Dechun Bioact Mater Article Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements. KeAi Publishing 2021-07-10 /pmc/articles/PMC8427090/ /pubmed/34541403 http://dx.doi.org/10.1016/j.bioactmat.2021.07.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Li, Meng
Bai, Jiaxiang
Tao, Huaqiang
Hao, Li
Yin, Weiling
Ren, Xiaoxue
Gao, Ang
Li, Ning
Wang, Miao
Fang, Shiyuan
Xu, Yaozeng
Chen, Liang
Yang, Huilin
Wang, Huaiyu
Pan, Guoqing
Geng, Dechun
Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title_full Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title_fullStr Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title_full_unstemmed Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title_short Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
title_sort rational integration of defense and repair synergy on peek osteoimplants via biomimetic peptide clicking strategy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427090/
https://www.ncbi.nlm.nih.gov/pubmed/34541403
http://dx.doi.org/10.1016/j.bioactmat.2021.07.002
work_keys_str_mv AT limeng rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT baijiaxiang rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT taohuaqiang rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT haoli rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT yinweiling rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT renxiaoxue rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT gaoang rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT lining rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT wangmiao rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT fangshiyuan rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT xuyaozeng rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT chenliang rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT yanghuilin rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT wanghuaiyu rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT panguoqing rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy
AT gengdechun rationalintegrationofdefenseandrepairsynergyonpeekosteoimplantsviabiomimeticpeptideclickingstrategy