High throughput screening of novel AAV capsids identifies variants for transduction of adult NSCs within the subventricular zone

The adult mammalian brain entails a reservoir of neural stem cells (NSCs) generating glial cells and neurons. However, NSCs become increasingly quiescent with age, which hampers their regenerative capacity. New means are therefore required to genetically modify adult NSCs for re-enabling endogenous...

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Detalles Bibliográficos
Autores principales: Kremer, Lukas P.M., Cerrizuela, Santiago, Dehler, Sascha, Stiehl, Thomas, Weinmann, Jonas, Abendroth, Heike, Kleber, Susanne, Laure, Alexander, El Andari, Jihad, Anders, Simon, Marciniak-Czochra, Anna, Grimm, Dirk, Martin-Villalba, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427210/
https://www.ncbi.nlm.nih.gov/pubmed/34553001
http://dx.doi.org/10.1016/j.omtm.2021.07.001

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