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Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak?
PURPOSE: Seasonal Hyperacute Panuveitis (SHAPU), is a mysterious blinding disease seen only in Nepal with a higher prevalence among children usually seen in autumn every alternate odd year since 1975. This report highlights the sporadic summer outbreak in the even years with atypical presentation. O...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427219/ https://www.ncbi.nlm.nih.gov/pubmed/34522825 http://dx.doi.org/10.1016/j.ajoc.2021.101198 |
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author | Gurung, Haramaya Kharel Sitaula, Ranju Karki, Pratap Khatri, Anadi Khanal, Bhaiya Joshi, Sagun Narayan Maharjan, Indraman Upadhyay, Madan Prasad |
author_facet | Gurung, Haramaya Kharel Sitaula, Ranju Karki, Pratap Khatri, Anadi Khanal, Bhaiya Joshi, Sagun Narayan Maharjan, Indraman Upadhyay, Madan Prasad |
author_sort | Gurung, Haramaya |
collection | PubMed |
description | PURPOSE: Seasonal Hyperacute Panuveitis (SHAPU), is a mysterious blinding disease seen only in Nepal with a higher prevalence among children usually seen in autumn every alternate odd year since 1975. This report highlights the sporadic summer outbreak in the even years with atypical presentation. OBSERVATIONS: Three patients were diagnosed as SHAPU in the summer (May) of 2020. All of them noted the presence of white moths (Gazalina species) in their environment with or without direct physical contact. The clinical patterns were severe in nature including corneal melting. Two out of three patients (66.6%) developed phthisis bulbi and lost their vision. CONCLUSIONS AND IMPORTANCE: White moth has been associated as a risk factor for SHAPU. Despite the known natural history of appearance after monsoon of every odd year, the few unhatched eggs of the moths may hatch under the favorable circumstances in the summer of the even years and may lead to the sporadic outbreak of SHAPU. Though less in numbers, the clinical presentation of such sporadic SHAPU cases may be atypical with less favorable outcome. |
format | Online Article Text |
id | pubmed-8427219 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84272192021-09-13 Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? Gurung, Haramaya Kharel Sitaula, Ranju Karki, Pratap Khatri, Anadi Khanal, Bhaiya Joshi, Sagun Narayan Maharjan, Indraman Upadhyay, Madan Prasad Am J Ophthalmol Case Rep Case Report PURPOSE: Seasonal Hyperacute Panuveitis (SHAPU), is a mysterious blinding disease seen only in Nepal with a higher prevalence among children usually seen in autumn every alternate odd year since 1975. This report highlights the sporadic summer outbreak in the even years with atypical presentation. OBSERVATIONS: Three patients were diagnosed as SHAPU in the summer (May) of 2020. All of them noted the presence of white moths (Gazalina species) in their environment with or without direct physical contact. The clinical patterns were severe in nature including corneal melting. Two out of three patients (66.6%) developed phthisis bulbi and lost their vision. CONCLUSIONS AND IMPORTANCE: White moth has been associated as a risk factor for SHAPU. Despite the known natural history of appearance after monsoon of every odd year, the few unhatched eggs of the moths may hatch under the favorable circumstances in the summer of the even years and may lead to the sporadic outbreak of SHAPU. Though less in numbers, the clinical presentation of such sporadic SHAPU cases may be atypical with less favorable outcome. Elsevier 2021-09-02 /pmc/articles/PMC8427219/ /pubmed/34522825 http://dx.doi.org/10.1016/j.ajoc.2021.101198 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Gurung, Haramaya Kharel Sitaula, Ranju Karki, Pratap Khatri, Anadi Khanal, Bhaiya Joshi, Sagun Narayan Maharjan, Indraman Upadhyay, Madan Prasad Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title | Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title_full | Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title_fullStr | Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title_full_unstemmed | Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title_short | Sporadic summer outbreak of SHAPU in even years: Does the pattern match with the usual autumn outbreak? |
title_sort | sporadic summer outbreak of shapu in even years: does the pattern match with the usual autumn outbreak? |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427219/ https://www.ncbi.nlm.nih.gov/pubmed/34522825 http://dx.doi.org/10.1016/j.ajoc.2021.101198 |
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