Shining light on location-biased cAMP signaling

cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein–coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explore...

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Detalles Bibliográficos
Autores principales: Vilardaga, Jean-Pierre, Sutkeviciute, Ieva, Peña, Karina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Editors' Pick Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427240/
https://www.ncbi.nlm.nih.gov/pubmed/34437901
http://dx.doi.org/10.1016/j.jbc.2021.101118
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author Vilardaga, Jean-Pierre
Sutkeviciute, Ieva
Peña, Karina A.
author_facet Vilardaga, Jean-Pierre
Sutkeviciute, Ieva
Peña, Karina A.
author_sort Vilardaga, Jean-Pierre
collection PubMed
description cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein–coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.
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spelling pubmed-84272402021-09-13 Shining light on location-biased cAMP signaling Vilardaga, Jean-Pierre Sutkeviciute, Ieva Peña, Karina A. J Biol Chem Editors' Pick Highlight cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein–coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses. American Society for Biochemistry and Molecular Biology 2021-08-23 /pmc/articles/PMC8427240/ /pubmed/34437901 http://dx.doi.org/10.1016/j.jbc.2021.101118 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editors' Pick Highlight
Vilardaga, Jean-Pierre
Sutkeviciute, Ieva
Peña, Karina A.
Shining light on location-biased cAMP signaling
title Shining light on location-biased cAMP signaling
title_full Shining light on location-biased cAMP signaling
title_fullStr Shining light on location-biased cAMP signaling
title_full_unstemmed Shining light on location-biased cAMP signaling
title_short Shining light on location-biased cAMP signaling
title_sort shining light on location-biased camp signaling
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427240/
https://www.ncbi.nlm.nih.gov/pubmed/34437901
http://dx.doi.org/10.1016/j.jbc.2021.101118
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