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TRPC5 mediates TMZ resistance in TMZ-resistant glioblastoma cells via NFATc3-P-gp pathway

P-glycoprotein (P-gp) acts as a pump to transport cytotoxic drugs out of cells and is upregulated in cancer cells. Suppressing the expression of P-gp is an effective strategy to overcome multidrug resistance in cancer chemotherapy. Temozolomide (TMZ) is the recommended drug for the standard treatmen...

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Detalles Bibliográficos
Autores principales:	Zou, Yan, Liu, Zi'xiang, Zhou, Yi'nan, Wang, Jing, Xu, Qin'yi, Zhao, Xu'dong, Miao, Zeng'li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427319/ https://www.ncbi.nlm.nih.gov/pubmed/34500231 http://dx.doi.org/10.1016/j.tranon.2021.101214

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