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The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine

Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is t...

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Autores principales: Tien Vo, Thi Thuy, Vo, Quang Canh, Tuan, Vo Phuoc, Wee, Yinshen, Cheng, Hsin-Chung, Lee, I-Ta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427320/
https://www.ncbi.nlm.nih.gov/pubmed/34507160
http://dx.doi.org/10.1016/j.redox.2021.102124
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author Tien Vo, Thi Thuy
Vo, Quang Canh
Tuan, Vo Phuoc
Wee, Yinshen
Cheng, Hsin-Chung
Lee, I-Ta
author_facet Tien Vo, Thi Thuy
Vo, Quang Canh
Tuan, Vo Phuoc
Wee, Yinshen
Cheng, Hsin-Chung
Lee, I-Ta
author_sort Tien Vo, Thi Thuy
collection PubMed
description Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is that they are able to deliver CO to the target sites in a controlled manner. There is an increasing body of experimental studies suggesting the therapeutic potentials of CO and CO-RMs in different cancer models. This review firstly presents a short but crucial view concerning the characteristics of CO and CO-RMs. Then, the anticancer activities of CO-RMs that target many cancer hallmarks, mainly proliferation, apoptosis, angiogenesis, and invasion and metastasis, are discussed. However, their anticancer activities are varying and cell-type specific. The aerobic metabolism of molecular oxygen inevitably generates various oxygen-containing reactive metabolites termed reactive oxygen species (ROS) which play important roles in both physiology and pathophysiology. Although ROS act as a double-edged sword in cancer, both sides of which may potentially have been exploited for therapeutic benefits. The main focus of the present review is thus to identify the possible signaling network by which CO-RMs can exert their anticancer actions, where ROS play the central role. Another important issue concerning the potential effect of CO-RMs on the aerobic glycolysis (the Warburg effect) which is a feature of cancer metabolic reprogramming is given before the conclusion with future prospects on the challenges of developing CO-RMs into clinically pharmaceutical candidates in cancer therapy.
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spelling pubmed-84273202021-09-13 The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine Tien Vo, Thi Thuy Vo, Quang Canh Tuan, Vo Phuoc Wee, Yinshen Cheng, Hsin-Chung Lee, I-Ta Redox Biol Review Article Carbon monoxide (CO) is now well recognized a pivotal endogenous signaling molecule in mammalian lives. The proof-of-concept employing chemical carriers of exogenous CO as prodrugs for CO release, also known as CO-releasing molecules (CO-RMs), has been appreciated. The major advantage of CO-RMs is that they are able to deliver CO to the target sites in a controlled manner. There is an increasing body of experimental studies suggesting the therapeutic potentials of CO and CO-RMs in different cancer models. This review firstly presents a short but crucial view concerning the characteristics of CO and CO-RMs. Then, the anticancer activities of CO-RMs that target many cancer hallmarks, mainly proliferation, apoptosis, angiogenesis, and invasion and metastasis, are discussed. However, their anticancer activities are varying and cell-type specific. The aerobic metabolism of molecular oxygen inevitably generates various oxygen-containing reactive metabolites termed reactive oxygen species (ROS) which play important roles in both physiology and pathophysiology. Although ROS act as a double-edged sword in cancer, both sides of which may potentially have been exploited for therapeutic benefits. The main focus of the present review is thus to identify the possible signaling network by which CO-RMs can exert their anticancer actions, where ROS play the central role. Another important issue concerning the potential effect of CO-RMs on the aerobic glycolysis (the Warburg effect) which is a feature of cancer metabolic reprogramming is given before the conclusion with future prospects on the challenges of developing CO-RMs into clinically pharmaceutical candidates in cancer therapy. Elsevier 2021-09-06 /pmc/articles/PMC8427320/ /pubmed/34507160 http://dx.doi.org/10.1016/j.redox.2021.102124 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Tien Vo, Thi Thuy
Vo, Quang Canh
Tuan, Vo Phuoc
Wee, Yinshen
Cheng, Hsin-Chung
Lee, I-Ta
The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title_full The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title_fullStr The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title_full_unstemmed The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title_short The potentials of carbon monoxide-releasing molecules in cancer treatment: An outlook from ROS biology and medicine
title_sort potentials of carbon monoxide-releasing molecules in cancer treatment: an outlook from ros biology and medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427320/
https://www.ncbi.nlm.nih.gov/pubmed/34507160
http://dx.doi.org/10.1016/j.redox.2021.102124
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