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NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT) plays a key role in antioxidant defense by mediating cystine uptake, promoting glutathione synthesis, and maintaining cell survival under oxidative stress conditions. Recent studies showed that, to prevent to...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaoguang, Zhang, Yilei, Zhuang, Li, Olszewski, Kellen, Gan, Boyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Chongqing Medical University 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427322/ https://www.ncbi.nlm.nih.gov/pubmed/34522704 http://dx.doi.org/10.1016/j.gendis.2020.11.010

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