The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3

The dysregulation of NLRP3 inflammasome plays a critical role in pathogenesis of various human inflammatory diseases, thus NLRP3 inflammasome activation must be tightly controlled at multiple levels. However, the underlying mechanism regulating NLRP3 inflammasome activation remains unclear. Herein,...

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Detalles Bibliográficos
Autores principales: Tang, Tiantian, Li, Ping, Zhou, Xinhui, Wang, Rui, Fan, Xiuqin, Yang, Mengyi, Qi, Kemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427430/
https://www.ncbi.nlm.nih.gov/pubmed/34512673
http://dx.doi.org/10.3389/fimmu.2021.741839

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