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Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging

BACKGROUND AND AIM: Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla (Phyllanthus emblica L.) branch has shown several benefits, but not the anti-skin aging. The study aimed to evaluate the anti-skin aging efficacy of amla branch. EXPERIMEN...

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Autores principales: Chaikul, Puxvadee, Kanlayavattanakul, Mayuree, Somkumnerd, Jariya, Lourith, Nattaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427479/
https://www.ncbi.nlm.nih.gov/pubmed/34522633
http://dx.doi.org/10.1016/j.jtcme.2021.02.004
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author Chaikul, Puxvadee
Kanlayavattanakul, Mayuree
Somkumnerd, Jariya
Lourith, Nattaya
author_facet Chaikul, Puxvadee
Kanlayavattanakul, Mayuree
Somkumnerd, Jariya
Lourith, Nattaya
author_sort Chaikul, Puxvadee
collection PubMed
description BACKGROUND AND AIM: Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla (Phyllanthus emblica L.) branch has shown several benefits, but not the anti-skin aging. The study aimed to evaluate the anti-skin aging efficacy of amla branch. EXPERIMENTAL PROCEDURE: Amla branches were standardized the phenolic acids. The extract was investigated anti-skin aging activities, including antioxidant, anti-tyrosinase, anti-melanogenesis, and matrix metalloproteinase-2 inhibitory assays. Topical gel containing extract was prepared and evaluated the skin irritation by a single closed patch test. Randomized, double-blind, placebo-control study was performed in 20 volunteers for 84 consecutive days. The tested skin was evaluated by Chromameter® CR 400, Dermalab® USB, Mexameter® MX 18, Corneometer® CM 825, and Visioscan® VC 98. RESULTS: Amla branch extract, a dark brown powder, consisted a variety of phenolic acids, mainly sinapic and ferulic acids. The extract exhibited the potent antioxidant and tyrosinase inhibitory activities in vitro assays and the melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular assays at 0.1 mg/mL. Topical gel containing 0.1% extract was a stable and safe formulation. Clinical study was proved the superior anti-skin aging efficacy, including the lightening skin color, the enhanced skin elasticity and hydration, and the skin wrinkle reduction. CONCLUSION: The study results suggested that amla branch is a rich source of bioactive compounds and can be a potential ingredient for utilization in anti-skin aging products.
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spelling pubmed-84274792021-09-13 Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging Chaikul, Puxvadee Kanlayavattanakul, Mayuree Somkumnerd, Jariya Lourith, Nattaya J Tradit Complement Med Original Article BACKGROUND AND AIM: Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla (Phyllanthus emblica L.) branch has shown several benefits, but not the anti-skin aging. The study aimed to evaluate the anti-skin aging efficacy of amla branch. EXPERIMENTAL PROCEDURE: Amla branches were standardized the phenolic acids. The extract was investigated anti-skin aging activities, including antioxidant, anti-tyrosinase, anti-melanogenesis, and matrix metalloproteinase-2 inhibitory assays. Topical gel containing extract was prepared and evaluated the skin irritation by a single closed patch test. Randomized, double-blind, placebo-control study was performed in 20 volunteers for 84 consecutive days. The tested skin was evaluated by Chromameter® CR 400, Dermalab® USB, Mexameter® MX 18, Corneometer® CM 825, and Visioscan® VC 98. RESULTS: Amla branch extract, a dark brown powder, consisted a variety of phenolic acids, mainly sinapic and ferulic acids. The extract exhibited the potent antioxidant and tyrosinase inhibitory activities in vitro assays and the melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular assays at 0.1 mg/mL. Topical gel containing 0.1% extract was a stable and safe formulation. Clinical study was proved the superior anti-skin aging efficacy, including the lightening skin color, the enhanced skin elasticity and hydration, and the skin wrinkle reduction. CONCLUSION: The study results suggested that amla branch is a rich source of bioactive compounds and can be a potential ingredient for utilization in anti-skin aging products. Elsevier 2021-02-09 /pmc/articles/PMC8427479/ /pubmed/34522633 http://dx.doi.org/10.1016/j.jtcme.2021.02.004 Text en © 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Chaikul, Puxvadee
Kanlayavattanakul, Mayuree
Somkumnerd, Jariya
Lourith, Nattaya
Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title_full Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title_fullStr Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title_full_unstemmed Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title_short Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging
title_sort phyllanthus emblica l. (amla) branch: a safe and effective ingredient against skin aging
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427479/
https://www.ncbi.nlm.nih.gov/pubmed/34522633
http://dx.doi.org/10.1016/j.jtcme.2021.02.004
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