Apoptosome Formation through Disruption of the K192-D616 Salt Bridge in the Apaf-1 Closed Form

[Image: see text] The molecular mechanism of apoptosome activation through conformational changes of Apaf-1 auto-inhibited form remains largely enigmatic. The crystal structure of Apaf-1 suggests that some ionic bonds, including the bond between K192 and D616, are critical for the preservation of th...

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Detalles Bibliográficos
Autores principales: Sahebazzamani, Fatemeh, Hosseinkhani, Saman, Eriksson, Leif A., Fearnhead, Howard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427654/
https://www.ncbi.nlm.nih.gov/pubmed/34514227
http://dx.doi.org/10.1021/acsomega.1c02274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427654/
https://www.ncbi.nlm.nih.gov/pubmed/34514227
http://dx.doi.org/10.1021/acsomega.1c02274

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