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Apoptosome Formation through Disruption of the K192-D616 Salt Bridge in the Apaf-1 Closed Form
[Image: see text] The molecular mechanism of apoptosome activation through conformational changes of Apaf-1 auto-inhibited form remains largely enigmatic. The crystal structure of Apaf-1 suggests that some ionic bonds, including the bond between K192 and D616, are critical for the preservation of th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427654/ https://www.ncbi.nlm.nih.gov/pubmed/34514227 http://dx.doi.org/10.1021/acsomega.1c02274 |