The Dual Targeting of FcRn and FcγRs via Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development...

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Detalles Bibliográficos
Autores principales: Monnet, Céline, Jacque, Emilie, de Romeuf, Christophe, Fontayne, Alexandre, Abache, Toufik, Fournier, Nathalie, Dupont, Gilles, Derache, Delphine, Engrand, Anais, Bauduin, Aurélie, Terrier, Aurélie, Seifert, Alexander, Beghin, Cécile, Longue, Alain, Masiello, Nicholas, Danino, Laetitia, Nogre, Michel, Raia, Anais, Dhainaut, Frederic, Fauconnier, Louis, Togbe, Dieudonnée, Reitinger, Carmen, Nimmerjahn, Falk, Stevens, Wil, Chtourou, Sami, Mondon, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427755/
https://www.ncbi.nlm.nih.gov/pubmed/34512662
http://dx.doi.org/10.3389/fimmu.2021.728322

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