Early Childhood Shigellosis and Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study with a Prolonged Follow-up

BACKGROUND: Although the short-term neurological complications of Shigella spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. METHODS: This is a retrospective population-base...

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Detalles Bibliográficos
Autores principales: Merzon, Eugene, Gutbir, Yuval, Vinker, Shlomo, Golan Cohen, Avivit, Horwitz, Dana, Ashkenazi, Shai, Sadaka, Yair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Current Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427818/
https://www.ncbi.nlm.nih.gov/pubmed/32698643
http://dx.doi.org/10.1177/1087054720940392
Descripción
Sumario:BACKGROUND: Although the short-term neurological complications of Shigella spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. METHODS: This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5–18 years who underwent stool culture prior to the age of 3 years. RESULTS: Of 52,761 children with a stool culture examined, 5,269 (9.98%) had Shigella-positive results. The rate of ADHD was 10.6% and 8.6% among children with Shigella-positive and Shigella-negative stool cultures, respectively (p < .001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13–1.29, p < .001). The younger the child was during Shigella gastroenteritis, the higher was the association with ADHD (p < .001). CONCLUSION: Early childhood shigellosis is associated with an increased rate of long-term ADHD.

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