Current understanding of ferroptosis in the progression and treatment of pancreatic cancer

Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accum...

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Detalles Bibliográficos
Autores principales: Dong, Shi, Li, Xin, Jiang, Wenkai, Chen, Zhou, Zhou, Wence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427874/
https://www.ncbi.nlm.nih.gov/pubmed/34503532
http://dx.doi.org/10.1186/s12935-021-02166-6
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author Dong, Shi
Li, Xin
Jiang, Wenkai
Chen, Zhou
Zhou, Wence
author_facet Dong, Shi
Li, Xin
Jiang, Wenkai
Chen, Zhou
Zhou, Wence
author_sort Dong, Shi
collection PubMed
description Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer.
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spelling pubmed-84278742021-09-10 Current understanding of ferroptosis in the progression and treatment of pancreatic cancer Dong, Shi Li, Xin Jiang, Wenkai Chen, Zhou Zhou, Wence Cancer Cell Int Review Pancreatic cancer is a highly malignant tumour of the digestive tract. Despite advances in treatment, its 5-year survival rate remains low, and its prognosis is the worst among all cancers; innovative therapeutic methods are needed. Ferroptosis is a form of regulatory cell death driven by iron accumulation and lipid peroxidation. Recent studies have found that ferroptosis plays an important role in the development and treatment response of tumours, particularly pancreatic cancer. This article reviews the current understanding of the mechanism of ferroptosis and ferroptosis-related treatment in pancreatic cancer. BioMed Central 2021-09-09 /pmc/articles/PMC8427874/ /pubmed/34503532 http://dx.doi.org/10.1186/s12935-021-02166-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dong, Shi
Li, Xin
Jiang, Wenkai
Chen, Zhou
Zhou, Wence
Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title_full Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title_fullStr Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title_full_unstemmed Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title_short Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
title_sort current understanding of ferroptosis in the progression and treatment of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427874/
https://www.ncbi.nlm.nih.gov/pubmed/34503532
http://dx.doi.org/10.1186/s12935-021-02166-6
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