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Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells

Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditional treatments can be partly attributed to the lack of understanding of the role of the tu...

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Autores principales: Li, Xiao, Zhu, Hongming, Sun, Weixuan, Yang, Xingru, Nie, Qing, Fang, Xuedong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427881/
https://www.ncbi.nlm.nih.gov/pubmed/34503536
http://dx.doi.org/10.1186/s12935-021-02121-5
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author Li, Xiao
Zhu, Hongming
Sun, Weixuan
Yang, Xingru
Nie, Qing
Fang, Xuedong
author_facet Li, Xiao
Zhu, Hongming
Sun, Weixuan
Yang, Xingru
Nie, Qing
Fang, Xuedong
author_sort Li, Xiao
collection PubMed
description Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditional treatments can be partly attributed to the lack of understanding of the role of the tumor stroma. For this reason, CAF targeting is gradually gaining attention, and many studies are trying to overcome the limitations of tumor treatment with CAF as a breakthrough. Glutamine (GLN) has been called a “nitrogen reservoir” for cancer cells because of its role in supporting anabolic processes such as fuel proliferation and nucleotide synthesis, but ammonia is a byproduct of the metabolism of GLN and other nitrogenous compounds. Moreover, in some studies, GLN has been reported as a fundamental nitrogen source that can support tumor biomass. In this review, we discuss the latest findings on the role of GLN and ammonia in the crosstalk between CAFs and cancer cells as well as the potential therapeutic implications of nitrogen metabolism.
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spelling pubmed-84278812021-09-10 Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells Li, Xiao Zhu, Hongming Sun, Weixuan Yang, Xingru Nie, Qing Fang, Xuedong Cancer Cell Int Review Cancer-associated fibroblasts (CAFs), the most abundant cells in the tumor microenvironment, play an indispensable role in cancer initiation, progression, metastasis, and metabolism. The limitations of traditional treatments can be partly attributed to the lack of understanding of the role of the tumor stroma. For this reason, CAF targeting is gradually gaining attention, and many studies are trying to overcome the limitations of tumor treatment with CAF as a breakthrough. Glutamine (GLN) has been called a “nitrogen reservoir” for cancer cells because of its role in supporting anabolic processes such as fuel proliferation and nucleotide synthesis, but ammonia is a byproduct of the metabolism of GLN and other nitrogenous compounds. Moreover, in some studies, GLN has been reported as a fundamental nitrogen source that can support tumor biomass. In this review, we discuss the latest findings on the role of GLN and ammonia in the crosstalk between CAFs and cancer cells as well as the potential therapeutic implications of nitrogen metabolism. BioMed Central 2021-09-09 /pmc/articles/PMC8427881/ /pubmed/34503536 http://dx.doi.org/10.1186/s12935-021-02121-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Li, Xiao
Zhu, Hongming
Sun, Weixuan
Yang, Xingru
Nie, Qing
Fang, Xuedong
Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title_full Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title_fullStr Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title_full_unstemmed Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title_short Role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
title_sort role of glutamine and its metabolite ammonia in crosstalk of cancer-associated fibroblasts and cancer cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427881/
https://www.ncbi.nlm.nih.gov/pubmed/34503536
http://dx.doi.org/10.1186/s12935-021-02121-5
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