Single-nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell-type-specific gene regulatory variation

BACKGROUND: Cell types in ventral midbrain are involved in diseases with variable genetic susceptibility, such as Parkinson’s disease and schizophrenia. Many genetic variants affect regulatory regions and alter gene expression in a cell-type-specific manner depending on the chromatin structure and a...

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Detalles Bibliográficos
Autores principales: Gui, Yujuan, Grzyb, Kamil, Thomas, Mélanie H., Ohnmacht, Jochen, Garcia, Pierre, Buttini, Manuel, Skupin, Alexander, Sauter, Thomas, Sinkkonen, Lasse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427957/
https://www.ncbi.nlm.nih.gov/pubmed/34503558
http://dx.doi.org/10.1186/s13072-021-00418-3

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