Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known risk factors in AD, including loss-of-function variants of TR...

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Detalles Bibliográficos
Autores principales: Delizannis, Argyro Thalia, Nonneman, Annelies, Tsering, Wangchen, De Bondt, An, Van den Wyngaert, Ilse, Zhang, Bin, Meymand, Emily, Olufemi, Modupe F., Koivula, Pyry, Maimaiti, Shaniya, Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428059/
https://www.ncbi.nlm.nih.gov/pubmed/34503586
http://dx.doi.org/10.1186/s40478-021-01251-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428059/
https://www.ncbi.nlm.nih.gov/pubmed/34503586
http://dx.doi.org/10.1186/s40478-021-01251-1

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