Cargando…

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Dystrophic neuronal processes harboring neuritic plaque (NP) tau pathology are found in association with Aβ plaques in Alzheimer’s disease (AD) brain. Microglia are also in proximity to these plaques and microglial gene variants are known risk factors in AD, including loss-of-function variants of TR...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delizannis, Argyro Thalia, Nonneman, Annelies, Tsering, Wangchen, De Bondt, An, Van den Wyngaert, Ilse, Zhang, Bin, Meymand, Emily, Olufemi, Modupe F., Koivula, Pyry, Maimaiti, Shaniya, Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428059/ https://www.ncbi.nlm.nih.gov/pubmed/34503586 http://dx.doi.org/10.1186/s40478-021-01251-1

Ejemplares similares

TREM2 function impedes tau seeding in neuritic plaques
por: Leyns, Cheryl E.G., et al.
Publicado: (2019)

Transformation of non-neuritic into neuritic plaques during AD progression drives cortical spread of tau pathology via regenerative failure
por: Tsering, Wangchen, et al.
Publicado: (2023)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
por: Zhao, Peng, et al.
Publicado: (2022)

Data on TREM-1 activation destabilizing carotid plaques
por: Rao, Velidi H., et al.
Publicado: (2016)

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
por: Ly, Philip T.T., et al.
Publicado: (2011)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014)

Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis
por: Mazumder, Srestha, et al.
Publicado: (2022)

Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Bhattacharya, Soumee, et al.
Publicado: (2014)

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
por: Ullah, Rahim, et al.
Publicado: (2021)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy
por: Baumann, Bernhard, et al.
Publicado: (2017)

The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
por: Li, Tong, et al.
Publicado: (2016)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
por: Ulrich, Jason D, et al.
Publicado: (2014)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
por: Sosna, Justyna, et al.
Publicado: (2018)

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
por: Kook, S-Y, et al.
Publicado: (2014)

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD
por: Boza-Serrano, Antonio, et al.
Publicado: (2018)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
por: Tsui, Ka Chun, et al.
Publicado: (2022)

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
por: Michael, Ralph, et al.
Publicado: (2017)

Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology
por: Laversenne, Vanessa, et al.
Publicado: (2020)

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Whitmore, Clayton A., et al.
Publicado: (2022)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model
por: Zhang, Bin, et al.
Publicado: (2018)

TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits
por: Joshi, Pranav, et al.
Publicado: (2021)

Plaque regression and plaque stabilisation in cardiovascular diseases
por: Dave, Tarun, et al.
Publicado: (2013)

Secondary Plaque Over Primary Plaque on Scalp
por: Pangti, Rashi, et al.
Publicado: (2021)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer’s Disease Model
por: Mackenzie-Gray Scott, Connie A., et al.
Publicado: (2022)

Correction: Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
por: Price, Brittani R., et al.
Publicado: (2020)

Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis
por: Sadleir, Katherine R., et al.
Publicado: (2022)

Atherosclerotic Plaque Biomarkers: Beyond the Horizon of the Vulnerable Plaque
por: W. van Lammeren, Guus, et al.
Publicado: (2011)

The Relation between Atherosclerosis Plaque Composition and Plaque Rupture
por: Babaniamansour, Parto, et al.
Publicado: (2020)

Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
por: Hellwig, Sabine, et al.
Publicado: (2015)

Correction: Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gg7edvl8cn8b7esg70ifl9a5k1