Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

BACKGROUND: The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases called tauopathies. Prior work has shown that a single P301L mutation in tau gene, MAPT, can promote alternative tau folding pathways that correlate with divergent clinical diagnoses. Using pr...

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Detalles Bibliográficos
Autores principales: Kang, Sang-Gyun, Han, Zhuang Zhuang, Daude, Nathalie, McNamara, Emily, Wohlgemuth, Serene, Molina-Porcel, Laura, Safar, Jiri G., Mok, Sue-Ann, Westaway, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428099/
https://www.ncbi.nlm.nih.gov/pubmed/34503506
http://dx.doi.org/10.1186/s12915-021-01132-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428099/
https://www.ncbi.nlm.nih.gov/pubmed/34503506
http://dx.doi.org/10.1186/s12915-021-01132-y

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