BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptional repression. However, the precise relationship between...

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Detalles Bibliográficos
Autores principales: Conway, Eric, Rossi, Federico, Fernandez-Perez, Daniel, Ponzo, Eleonora, Ferrari, Karin Johanna, Zanotti, Marika, Manganaro, Daria, Rodighiero, Simona, Tamburri, Simone, Pasini, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428331/
https://www.ncbi.nlm.nih.gov/pubmed/34186021
http://dx.doi.org/10.1016/j.molcel.2021.06.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428331/
https://www.ncbi.nlm.nih.gov/pubmed/34186021
http://dx.doi.org/10.1016/j.molcel.2021.06.020

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