Cargando…

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that appear to be largely successful in stopping infection. However, therapeutics that can help manage the disease are still required until immunity has been achieved globally. The identification of repurposed drugs that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pickard, Adam, Calverley, Ben C., Chang, Joan, Garva, Richa, Gago, Sara, Lu, Yinhui, Kadler, Karl E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428568/ https://www.ncbi.nlm.nih.gov/pubmed/34499689 http://dx.doi.org/10.1371/journal.ppat.1009840

Ejemplares similares

Preservation of circadian rhythms by the protein folding chaperone, BiP
por: Pickard, Adam, et al.
Publicado: (2019)

Dynamic High-Sensitivity Quantitation of Procollagen-I by Endogenous CRISPR-Cas9 NanoLuciferase Tagging
por: Calverley, Ben C., et al.
Publicado: (2020)

Slow Stretching That Mimics Embryonic Growth Rate Stimulates Structural and Mechanical Development of Tendon-Like Tissue In Vitro
por: Kalson, Nicholas S, et al.
Publicado: (2011)

Arhgap28 Is a RhoGAP that Inactivates RhoA and Downregulates Stress Fibers
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2014)

Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ
por: Canty-Laird, Elizabeth G., et al.
Publicado: (2011)

SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
por: Murgolo, Nicholas, et al.
Publicado: (2021)

Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19
por: Toor, Himanshu G., et al.
Publicado: (2021)

Comments on potential re-purposing of medicines against high-altitude illnesses towards SARS-CoV2: possibilities and pitfalls
por: Ahmad, Yasmin, et al.
Publicado: (2021)

Neuronal migration re-purposes mechanisms of cytokinesis
por: Falnikar, Aditi, et al.
Publicado: (2013)

New Indications and a Sense of (Re)purpose
Publicado: (2015)

Re-purposing software for functional characterization of the microbiome
por: Gardiner, Laura-Jayne, et al.
Publicado: (2021)

Eliminating Candida albicans for endodontic treatment purposes during the SARS-CoV-2 pandemic
por: Nasiri, Kaveh, et al.
Publicado: (2023)

Using “old” medications to fight new COVID-19: Re-purposing with a purpose
por: Wang, Yibin, et al.
Publicado: (2020)

SARS-CoV-2: from its discovery to genome structure, transcription, and replication
por: Brant, Ayslan Castro, et al.
Publicado: (2021)

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?
por: Foley, Daniel J., et al.
Publicado: (2016)

Re-purposing of hepatitis C virus FDA approved direct acting antivirals as potential SARS-CoV-2 protease inhibitors
por: Uddin, Reaz, et al.
Publicado: (2022)

Slowing Replication in Preparation for Reduction
por: Lawrence, Katherine S., et al.
Publicado: (2012)

SARS-CoV-2 replicates in the human testis with slow kinetics and has no major deleterious effects ex vivo
por: Mahé, Dominique, et al.
Publicado: (2023)

Editorial: Drug re-purposing for the treatment of bacterial infections
por: Tomás, María, et al.
Publicado: (2022)

Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription
por: Rajendran, Ramkumar, et al.
Publicado: (2011)

SARS-CoV2 vaccines: Slow is fast
por: Green, Douglas R.
Publicado: (2020)

A structure-based extracellular matrix expansion mechanism of fibrous tissue growth
por: Kalson, Nicholas S, et al.
Publicado: (2015)

Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables
por: Weyerhäuser, Patrick, et al.
Publicado: (2018)

Editorial: Drug Re-purposing for the Treatment of Bacterial and Viral Infections
por: García-Contreras, Rodolfo, et al.
Publicado: (2019)

(Re)thinking the city of proximity for Salutogenic purposes: Andrea Rebecchi
por: Rebecchi, A, et al.
Publicado: (2022)

Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon
por: Canty, Elizabeth G., et al.
Publicado: (2004)

Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3
por: Kapacee, Zoher, et al.
Publicado: (2010)

Collagen fibril assembly: New approaches to unanswered questions
por: Revell, Christopher K., et al.
Publicado: (2021)

Did border closures slow SARS-CoV-2?
por: Shiraef, Mary A., et al.
Publicado: (2022)

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes
por: Lautié, Emmanuelle, et al.
Publicado: (2020)

Re-purposing of domestic steam disinfectors within the hospital-at-home setting
por: Millar, Beverley C., et al.
Publicado: (2021)

Evaluation of mechanisms of action of re-purposed drugs for treatment of COVID-19
por: Rajaiah, Rajesh, et al.
Publicado: (2020)

Fit for Purpose—Re-Designing Australia’s Mental Health Information System
por: Rosenberg, Sebastian, et al.
Publicado: (2022)

Slow and steady is the key to β-cell replication
por: Brennand, Kristen, et al.
Publicado: (2009)

Multifork chromosome replication in slow-growing bacteria
por: Trojanowski, Damian, et al.
Publicado: (2017)

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin
por: Zigrino, Paola, et al.
Publicado: (2016)

Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology
por: Ben Shoham, Adi, et al.
Publicado: (2016)

In silico discovery of non-psychoactive scaffolds in Cannabis halting SARS-CoV-2 host entry and replication machinery
por: Khattab, Amira R, et al.
Publicado: (2022)

Too Slow, Less Dough for SARS-CoV-2 Tests? A Micro-Comic Strip
por: McAdam, Alexander J.
Publicado: (2021)

Live imaging of collagen deposition during skin development and repair in a collagen I – GFP fusion transgenic zebrafish line
por: Morris, Josephine L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_jvghi3l54ur6lkrr7k2cvqvnol